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学科主题物理化学
Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction
Liu, Zhongshan1,2; Ou, Junjie1; Lin, Hui1,2; Wang, Hongwei1; Dong, Jing1; Zou, Hanfa1; Ou JJ(欧俊杰); Zou HF(邹汉法)
关键词Hybrid Monolith Thiol-ene Reaction Disulfide Bond Ring-opening Polymerization Polyhedral Oligomeric Silsesquioxane
刊名JOURNAL OF CHROMATOGRAPHY A
2014-05-16
ISSN0021-9673
DOI10.1016/j.chroma.2014.03.058
1342页:70-77
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1809
产权排名待补充
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]CAPILLARY LIQUID-CHROMATOGRAPHY ; FACILE PREPARATION ; STATIONARY PHASES ; SEPARATION MEDIA ; POROUS PROPERTIES ; HIGH-EFFICIENCY ; COLUMNS ; ELECTROCHROMATOGRAPHY ; PERFORMANCE ; CHEMISTRY
英文摘要A polyhedral oligomeric silsesquioxane (POSS) hybrid monolith was simply prepared by using octaglycidyldimethylsily1 POSS (PUSS-epoxy) and cystamine dihydrochloride as monomers via ring-opening polymerization. The effects of composition of prepolymerization solution and polycondensation temperature on the morphology and permeability of monolithic column were investigated in detail. The obtained PUSS hybrid monolithic column showed 3D skeleton morphology and exhibited high column efficiency of 71,000 plates per meter in reversed-phase mechanism. Owing to this PUSS hybrid monolith essentially possessing a great number of disulfide bonds, the monolith surface would expose thiol groups after reduction with dithiothreitol (DTT), which supplied active sites to functionalize with various alkene monomers via thiol-ene click reaction. The results indicated that the reduction with OTT could not destroy the 3D skeleton of hybrid monolith. Both stearyl methylacrylate (SMA) and benzyl methacrylate (BMA) were selected to functionalize the hybrid monolithic columns for reversed-phase liquid chromatography (RPLC), while [2-(methacryloyloxy)ethyll-dimethyl-(3-sulfopropyI)-ammonium hydroxide (MSA) was used to modify the hybrid monolithic column in hydrophilic interaction chromatography (HILIC). These modified hybrid monolithic columns could be successfully applied for separation of small molecules with high efficiency. It is demonstrated that thiol-ene click reaction supplies a facile way to introduce various functional groups to the hybrid monolith possessing thiol groups. Furthermore, due to good permeability of the resulting hybrid monoliths, we also prepared long hybrid monolithic columns in narrow-bore capillaries. The highest column efficiency reached to 70,000 plates using a 1-m-long column of 75 im i.d. with a peak capacity of 147 for isocratic chromatography, indicating potential application in separation and analysis of complex biosamples. (C) 2014 Published by Elsevier B.V.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000335804500010
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119816
专题中国科学院大连化学物理研究所
通讯作者Ou JJ(欧俊杰); Zou HF(邹汉法)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Liu, Zhongshan,Ou, Junjie,Lin, Hui,et al. Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1342:70-77.
APA Liu, Zhongshan.,Ou, Junjie.,Lin, Hui.,Wang, Hongwei.,Dong, Jing.,...&邹汉法.(2014).Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction.JOURNAL OF CHROMATOGRAPHY A,1342,70-77.
MLA Liu, Zhongshan,et al."Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction".JOURNAL OF CHROMATOGRAPHY A 1342(2014):70-77.
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