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学科主题: 物理化学
题名: Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction
作者: Liu, Zhongshan1, 2;  Ou, Junjie1;  Lin, Hui1, 2;  Wang, Hongwei1;  Dong, Jing1;  Zou, Hanfa1
通讯作者: 欧俊杰 ;  邹汉法
关键词: Hybrid monolith ;  Thiol-ene reaction ;  Disulfide bond ;  Ring-opening polymerization ;  Polyhedral oligomeric silsesquioxane
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2014-05-16
DOI: 10.1016/j.chroma.2014.03.058
卷: 1342, 页:70-77
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
资助者: 1,1
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A polyhedral oligomeric silsesquioxane (POSS) hybrid monolith was simply prepared by using octaglycidyldimethylsily1 POSS (PUSS-epoxy) and cystamine dihydrochloride as monomers via ring-opening polymerization. The effects of composition of prepolymerization solution and polycondensation temperature on the morphology and permeability of monolithic column were investigated in detail. The obtained PUSS hybrid monolithic column showed 3D skeleton morphology and exhibited high column efficiency of 71,000 plates per meter in reversed-phase mechanism. Owing to this PUSS hybrid monolith essentially possessing a great number of disulfide bonds, the monolith surface would expose thiol groups after reduction with dithiothreitol (DTT), which supplied active sites to functionalize with various alkene monomers via thiol-ene click reaction. The results indicated that the reduction with OTT could not destroy the 3D skeleton of hybrid monolith. Both stearyl methylacrylate (SMA) and benzyl methacrylate (BMA) were selected to functionalize the hybrid monolithic columns for reversed-phase liquid chromatography (RPLC), while [2-(methacryloyloxy)ethyll-dimethyl-(3-sulfopropyI)-ammonium hydroxide (MSA) was used to modify the hybrid monolithic column in hydrophilic interaction chromatography (HILIC). These modified hybrid monolithic columns could be successfully applied for separation of small molecules with high efficiency. It is demonstrated that thiol-ene click reaction supplies a facile way to introduce various functional groups to the hybrid monolith possessing thiol groups. Furthermore, due to good permeability of the resulting hybrid monoliths, we also prepared long hybrid monolithic columns in narrow-bore capillaries. The highest column efficiency reached to 70,000 plates using a 1-m-long column of 75 im i.d. with a peak capacity of 147 for isocratic chromatography, indicating potential application in separation and analysis of complex biosamples. (C) 2014 Published by Elsevier B.V.
关键词[WOS]: CAPILLARY LIQUID-CHROMATOGRAPHY ;  FACILE PREPARATION ;  STATIONARY PHASES ;  SEPARATION MEDIA ;  POROUS PROPERTIES ;  HIGH-EFFICIENCY ;  COLUMNS ;  ELECTROCHROMATOGRAPHY ;  PERFORMANCE ;  CHEMISTRY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000335804500010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119816
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Liu, Zhongshan,Ou, Junjie,Lin, Hui,et al. Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1342:70-77.
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