DICP OpenIR
Subject Area物理化学
Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction
Liu, Zhongshan1,2; Ou, Junjie1; Lin, Hui1,2; Wang, Hongwei1; Dong, Jing1; Zou, Hanfa1; Ou JJ(欧俊杰); Zou HF(邹汉法)
KeywordHybrid Monolith Thiol-ene Reaction Disulfide Bond Ring-opening Polymerization Polyhedral Oligomeric Silsesquioxane
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2014-05-16
ISSN0021-9673
DOI10.1016/j.chroma.2014.03.058
Volume1342Pages:70-77
Indexed BySCI
Cooperation Status
SubtypeArticle
Department18
Funding Project1809
Contribution Rank待补充
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordCAPILLARY LIQUID-CHROMATOGRAPHY ; FACILE PREPARATION ; STATIONARY PHASES ; SEPARATION MEDIA ; POROUS PROPERTIES ; HIGH-EFFICIENCY ; COLUMNS ; ELECTROCHROMATOGRAPHY ; PERFORMANCE ; CHEMISTRY
AbstractA polyhedral oligomeric silsesquioxane (POSS) hybrid monolith was simply prepared by using octaglycidyldimethylsily1 POSS (PUSS-epoxy) and cystamine dihydrochloride as monomers via ring-opening polymerization. The effects of composition of prepolymerization solution and polycondensation temperature on the morphology and permeability of monolithic column were investigated in detail. The obtained PUSS hybrid monolithic column showed 3D skeleton morphology and exhibited high column efficiency of 71,000 plates per meter in reversed-phase mechanism. Owing to this PUSS hybrid monolith essentially possessing a great number of disulfide bonds, the monolith surface would expose thiol groups after reduction with dithiothreitol (DTT), which supplied active sites to functionalize with various alkene monomers via thiol-ene click reaction. The results indicated that the reduction with OTT could not destroy the 3D skeleton of hybrid monolith. Both stearyl methylacrylate (SMA) and benzyl methacrylate (BMA) were selected to functionalize the hybrid monolithic columns for reversed-phase liquid chromatography (RPLC), while [2-(methacryloyloxy)ethyll-dimethyl-(3-sulfopropyI)-ammonium hydroxide (MSA) was used to modify the hybrid monolithic column in hydrophilic interaction chromatography (HILIC). These modified hybrid monolithic columns could be successfully applied for separation of small molecules with high efficiency. It is demonstrated that thiol-ene click reaction supplies a facile way to introduce various functional groups to the hybrid monolith possessing thiol groups. Furthermore, due to good permeability of the resulting hybrid monoliths, we also prepared long hybrid monolithic columns in narrow-bore capillaries. The highest column efficiency reached to 70,000 plates using a 1-m-long column of 75 im i.d. with a peak capacity of 147 for isocratic chromatography, indicating potential application in separation and analysis of complex biosamples. (C) 2014 Published by Elsevier B.V.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
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WOS IDWOS:000335804500010
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119816
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu JJ(欧俊杰); Zou HF(邹汉法)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhongshan,Ou, Junjie,Lin, Hui,et al. Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1342:70-77.
APA Liu, Zhongshan.,Ou, Junjie.,Lin, Hui.,Wang, Hongwei.,Dong, Jing.,...&邹汉法.(2014).Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction.JOURNAL OF CHROMATOGRAPHY A,1342,70-77.
MLA Liu, Zhongshan,et al."Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction".JOURNAL OF CHROMATOGRAPHY A 1342(2014):70-77.
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