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学科主题: 物理化学
题名: Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
作者: Gao, Wei1, 2;  Sun, Hai-Xi3;  Xiao, Hongbin4;  Cui, Guanghong1;  Hillwig, Matthew L.5;  Jackson, Alana5;  Wang, Xiao1;  Shen, Ye1;  Zhao, Nan4;  Zhang, Liangxiao4;  Wang, Xiu-Jie3;  Peters, Reuben J.5;  Huang, Luqi1
通讯作者: Xiu-Jie Wang ;  Reuben J Peters ;  Luqi Huang
刊名: BMC GENOMICS
发表日期: 2014-01-28
DOI: 10.1186/1471-2164-15-73
卷: 15, 期:73, 页:1
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology ;  Genetics & Heredity
资助者: 4,3
研究领域[WOS]: Biotechnology & Applied Microbiology ;  Genetics & Heredity
英文摘要: Background: Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access. While elucidation of the underlying biosynthetic processes might help alleviate these issues (e. g., via metabolic engineering), investigation of this is hindered by the low levels of relevant gene expression and expansion of the corresponding enzymatic gene families. However, the often-inducible nature of such metabolic processes enables selection of those genes whose expression pattern indicates a role in production of the targeted natural product.
关键词[WOS]: HAIRY-ROOT CULTURE ;  ISOPRENOID BIOSYNTHESIS ;  MASS-SPECTROMETRY ;  GENE-EXPRESSION ;  YEAST ELICITOR ;  PATHWAYS ;  RICE ;  ENHANCEMENT ;  METABOLISM ;  ACTIVATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000331116500003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119824
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing 100700, Peoples R China
2.Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
5.Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA

Recommended Citation:
Gao, Wei,Sun, Hai-Xi,Xiao, Hongbin,et al. Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza[J]. BMC GENOMICS,2014,15(73):1.
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