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题名: DNA Catalyzed Dithioacetalization in Water
作者: Wang Changhao1;  Li Yinghao1;  Jia Guoqing1;  Lu Shengmei1;  Liu Yan1;  Li Can1
关键词: double-stranded DNA ;  herring sperm ;  catalysis ;  dithioacetalization ;  water medium ;  phosphate group
刊名: ACTA CHIMICA SINICA
发表日期: 2013-01-15
DOI: 10.6023/A12121089
卷: 71, 期:1, 页:36-39
收录类别: SCI ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The most popular hypothesis of precellular life is the "RNA World", which is utilizing RNA as both genetic as well as catalytic material. The chemical similarity between RNA and DNA leads researchers to investigate whether DNA has the catalytic function, although DNA is commonly viewed as a genetic carrier with a ubiquitous double-stranded architecture in living world. Nevertheless, the catalytic DNA has not been discovered in nature to date. In recent years, the catalytic function of DNA in nonbiological applications has aroused much interest to chemists in chemical synthesis such as DNA-templated organic synthesis and DNA-based asymmetric catalysis. However, the investigation of DNA as a direct catalyst for organic synthesis is largely elusive. Here we report that double-stranded DNA from herring sperm can catalyze the dithioacetalization in water for a wide range of aldehydes under mild reaction conditions. It is proposed that the phosphate groups of DNA together with the duplex architecture are responsible for the catalytic reaction.
关键词[WOS]: CHEMOSELECTIVE DITHIOACETALIZATION ;  CARBONYL-COMPOUNDS ;  ORGANIC-SYNTHESIS ;  EFFICIENT CATALYST ;  ALDOL REACTION ;  AQUEOUS-MEDIA ;  RNA WORLD ;  ACID ;  THIOACETALIZATION ;  ALDEHYDES
语种: 英语
WOS记录号: WOS:000315605300003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137473
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Wang Changhao,Li Yinghao,Jia Guoqing,et al. DNA Catalyzed Dithioacetalization in Water[J]. ACTA CHIMICA SINICA,2013,71(1):36-39.
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