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题名: Novel Hybrid Structure Silica/CdTe/Molecularly Imprinted Polymer: Synthesis, Specific Recognition, and Quantitative Fluorescence Detection of Bovine Hemoglobin
作者: Li, Dong-Yan1, 2, 3;  He, Xi-Wen1, 2, 3;  Chen, Yang1, 2, 3;  Li, Wen-You1, 2, 3;  Zhang, Yu-Kui1, 2, 3, 4
关键词: molecularly imprinted polymer ;  quantum dots ;  fluorescent detection ;  protein recognition
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2013-12-11
DOI: 10.1021/am403942y
卷: 5, 期:23, 页:12609-12616
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ;  Materials Science
英文摘要: This work presented a novel strategy for the synthesis of the hybrid structure silica/CdTe/molecularly imprinted polymer (Si-NP/CdTe/MIP) to recognize and detect the template bovine hemoglobin (BHb). First, amino-functionalized silica nanoparticles (Si-NP) and carboxyl-terminated CdTe quantum dots (QDs) were assembled into composite nanoparticles (Si-NP/CdTe) using the EDC (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) chemistry. Next, Si-NP/CdTe/MIP was synthesized by anchoring molecularly imprinted polymer (MIP) layer on the surface of Si-NP/CdTe through the sol-gel technique and surface imprinting technique. The hybrid structure possessed the selectivity of molecular imprinting technique and the sensitivity of CdTe QDs as well as well-defined morphology. The binding experiment and fluorescence method demonstrated its special recognition performance toward the template BHb. Under the optimized conditions, the fluorescence intensity of the Si-NP/CdTe/MIP decreased linearly with the increase of BHb in the concentration range 0.02-2.1 mu M, and the detection limit was 9.4 nM. Moreover, the reusability and reproducibility and the successful applications in practical samples indicated the synthesis of Si-NP/CdTe/MIP provided an alternative solution for special recognition and determination of protein from real samples.
关键词[WOS]: CDTE QUANTUM DOTS ;  SILICA NANOPARTICLES ;  PROTEIN ;  SURFACE ;  NANOCRYSTALS ;  BIOAPPLICATIONS ;  HYDROLYSIS
语种: 英语
WOS记录号: WOS:000328439600051
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137482
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
3.Synerget Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Li, Dong-Yan,He, Xi-Wen,Chen, Yang,et al. Novel Hybrid Structure Silica/CdTe/Molecularly Imprinted Polymer: Synthesis, Specific Recognition, and Quantitative Fluorescence Detection of Bovine Hemoglobin[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(23):12609-12616.
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