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题名: Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS
作者: Chen, Shili1;  Yin, Peiyuan1;  Zhao, Xinjie1;  Xing, Wenbin2;  Hu, Chunxiu1;  Zhou, Lina1;  Xu, Guowang1
关键词: Lipidomics ;  LC-MS ;  Liver disease ;  Metabolomics ;  Phospholipids
刊名: ELECTROPHORESIS
发表日期: 2013-10-01
DOI: 10.1002/elps.201200629
卷: 34, 期:19, 页:2848-2856
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In this study, an ultra fast LC/IT-TOF MS (UFLC/IT-TOF MS)-based serum lipidomics method was employed to characterize the serum lipid profile of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). After data collection and processing, 96 lipids including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins, triacylglycerides, and cholesterol esters were identified and used for subsequent data analysis. Partial least squares-discriminant analysis revealed that patients with liver diseases had distinctly different serum lipid profile from that of healthy controls; while cirrhosis and HCC patients had a similar serum lipid profile, but different from that of hepatitis patients. The ANOVA analysis found 75 of the 96 identified lipids to be abnormally regulated, among which most of these lipids were downregulated in cirrhosis and HCC patients compared with those of healthy controls and hepatitis patients, while hepatitis patients induced several lipids downregulated and others upregulated compared with those of healthy controls, indicating the aberrant lipid metabolism in patients with liver diseases. This work demonstrated the utility of UFLC/IT-TOF MS-based serum lipidomics as a powerful tool to investigate the lipid metabolism of liver diseases.
关键词[WOS]: PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE ;  NONALCOHOLIC FATTY LIVER ;  ACUTE VIRAL-HEPATITIS ;  LYSOPHOSPHATIDIC ACID ;  MASS SPECTROMETRY ;  C VIRUS ;  IN-SITU ;  CANCER ;  METABOLISM ;  EXPRESSION
语种: 英语
WOS记录号: WOS:000327667800009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137498
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sixth Peoples Hosp Dalian, Dalian, Peoples R China

Recommended Citation:
Chen, Shili,Yin, Peiyuan,Zhao, Xinjie,et al. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS[J]. ELECTROPHORESIS,2013,34(19):2848-2856.
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