DICP OpenIR
Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS
Chen, Shili1; Yin, Peiyuan1; Zhao, Xinjie1; Xing, Wenbin2; Hu, Chunxiu1; Zhou, Lina1; Xu, Guowang1
KeywordLipidomics Lc-ms Liver Disease Metabolomics Phospholipids
Source PublicationELECTROPHORESIS
2013-10-01
DOI10.1002/elps.201200629
Volume34Issue:19Pages:2848-2856
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE ; NONALCOHOLIC FATTY LIVER ; ACUTE VIRAL-HEPATITIS ; LYSOPHOSPHATIDIC ACID ; MASS SPECTROMETRY ; C VIRUS ; IN-SITU ; CANCER ; METABOLISM ; EXPRESSION
AbstractIn this study, an ultra fast LC/IT-TOF MS (UFLC/IT-TOF MS)-based serum lipidomics method was employed to characterize the serum lipid profile of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). After data collection and processing, 96 lipids including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins, triacylglycerides, and cholesterol esters were identified and used for subsequent data analysis. Partial least squares-discriminant analysis revealed that patients with liver diseases had distinctly different serum lipid profile from that of healthy controls; while cirrhosis and HCC patients had a similar serum lipid profile, but different from that of hepatitis patients. The ANOVA analysis found 75 of the 96 identified lipids to be abnormally regulated, among which most of these lipids were downregulated in cirrhosis and HCC patients compared with those of healthy controls and hepatitis patients, while hepatitis patients induced several lipids downregulated and others upregulated compared with those of healthy controls, indicating the aberrant lipid metabolism in patients with liver diseases. This work demonstrated the utility of UFLC/IT-TOF MS-based serum lipidomics as a powerful tool to investigate the lipid metabolism of liver diseases.
Language英语
WOS IDWOS:000327667800009
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/137498
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sixth Peoples Hosp Dalian, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Chen, Shili,Yin, Peiyuan,Zhao, Xinjie,et al. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS[J]. ELECTROPHORESIS,2013,34(19):2848-2856.
APA Chen, Shili.,Yin, Peiyuan.,Zhao, Xinjie.,Xing, Wenbin.,Hu, Chunxiu.,...&Xu, Guowang.(2013).Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS.ELECTROPHORESIS,34(19),2848-2856.
MLA Chen, Shili,et al."Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS".ELECTROPHORESIS 34.19(2013):2848-2856.
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