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Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS
Chen, Shili1; Yin, Peiyuan1; Zhao, Xinjie1; Xing, Wenbin2; Hu, Chunxiu1; Zhou, Lina1; Xu, Guowang1
关键词Lipidomics Lc-ms Liver Disease Metabolomics Phospholipids
刊名ELECTROPHORESIS
2013-10-01
DOI10.1002/elps.201200629
34期:19页:2848-2856
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE ; NONALCOHOLIC FATTY LIVER ; ACUTE VIRAL-HEPATITIS ; LYSOPHOSPHATIDIC ACID ; MASS SPECTROMETRY ; C VIRUS ; IN-SITU ; CANCER ; METABOLISM ; EXPRESSION
英文摘要In this study, an ultra fast LC/IT-TOF MS (UFLC/IT-TOF MS)-based serum lipidomics method was employed to characterize the serum lipid profile of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). After data collection and processing, 96 lipids including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins, triacylglycerides, and cholesterol esters were identified and used for subsequent data analysis. Partial least squares-discriminant analysis revealed that patients with liver diseases had distinctly different serum lipid profile from that of healthy controls; while cirrhosis and HCC patients had a similar serum lipid profile, but different from that of hepatitis patients. The ANOVA analysis found 75 of the 96 identified lipids to be abnormally regulated, among which most of these lipids were downregulated in cirrhosis and HCC patients compared with those of healthy controls and hepatitis patients, while hepatitis patients induced several lipids downregulated and others upregulated compared with those of healthy controls, indicating the aberrant lipid metabolism in patients with liver diseases. This work demonstrated the utility of UFLC/IT-TOF MS-based serum lipidomics as a powerful tool to investigate the lipid metabolism of liver diseases.
语种英语
WOS记录号WOS:000327667800009
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被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137498
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sixth Peoples Hosp Dalian, Dalian, Peoples R China
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Chen, Shili,Yin, Peiyuan,Zhao, Xinjie,et al. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS[J]. ELECTROPHORESIS,2013,34(19):2848-2856.
APA Chen, Shili.,Yin, Peiyuan.,Zhao, Xinjie.,Xing, Wenbin.,Hu, Chunxiu.,...&Xu, Guowang.(2013).Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS.ELECTROPHORESIS,34(19),2848-2856.
MLA Chen, Shili,et al."Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS".ELECTROPHORESIS 34.19(2013):2848-2856.
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