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Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein
Chen, Yang1; He, Xi-Wen1; Mao, Jie1; Li, Wen-You1; Zhang, Yu-Kui1,2,3
KeywordEtching Hollow Core Lysozyme Molecularly Imprinted Polymers Protein Separation
Source PublicationJOURNAL OF SEPARATION SCIENCE
2013-10-01
DOI10.1002/jssc.201300709
Volume36Issue:20Pages:3449-3456
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSILICA NANOPARTICLES ; SURFACE ; RECOGNITION ; ANTIBODIES ; DOXORUBICIN ; RECEPTORS ; MEMBRANE ; STRATEGY ; CAPTURE
AbstractProtein-imprinted polymers with hollow cores that have a super-high imprinting factor were prepared by etching the core of the surface-imprinted polymers that used silica particles as the support. Lysozyme as template was modified onto the surface of silica particles by a covalent method, and after polymerization and the removal of template molecules, channels through the polymer layer were formed, which allowed a single-protein molecule to come into the hollow core and attach to the binding sites inside the polymer layer. The adsorption experiments demonstrated that the hollow imprinted polymers had an extremely high binding capacity and selectivity, and thus a super-high imprinting factor was obtained. The as-prepared imprinted polymers were used to separate the template lysozyme from egg white successfully, indicating its high selectivity and potential application in the field of separation of protein from real samples.
Language英语
WOS IDWOS:000325482500020
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/137593
Collection中国科学院大连化学物理研究所
Affiliation1.Nankai Univ, Dept Chem, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Synerget Innovat Ctr Chem Sci & Engn Tianjin, Tianjin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Chen, Yang,He, Xi-Wen,Mao, Jie,et al. Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein[J]. JOURNAL OF SEPARATION SCIENCE,2013,36(20):3449-3456.
APA Chen, Yang,He, Xi-Wen,Mao, Jie,Li, Wen-You,&Zhang, Yu-Kui.(2013).Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein.JOURNAL OF SEPARATION SCIENCE,36(20),3449-3456.
MLA Chen, Yang,et al."Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein".JOURNAL OF SEPARATION SCIENCE 36.20(2013):3449-3456.
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