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Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein
Chen, Yang1; He, Xi-Wen1; Mao, Jie1; Li, Wen-You1; Zhang, Yu-Kui1,2,3
关键词Etching Hollow Core Lysozyme Molecularly Imprinted Polymers Protein Separation
刊名JOURNAL OF SEPARATION SCIENCE
2013-10-01
DOI10.1002/jssc.201300709
36期:20页:3449-3456
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]SILICA NANOPARTICLES ; SURFACE ; RECOGNITION ; ANTIBODIES ; DOXORUBICIN ; RECEPTORS ; MEMBRANE ; STRATEGY ; CAPTURE
英文摘要Protein-imprinted polymers with hollow cores that have a super-high imprinting factor were prepared by etching the core of the surface-imprinted polymers that used silica particles as the support. Lysozyme as template was modified onto the surface of silica particles by a covalent method, and after polymerization and the removal of template molecules, channels through the polymer layer were formed, which allowed a single-protein molecule to come into the hollow core and attach to the binding sites inside the polymer layer. The adsorption experiments demonstrated that the hollow imprinted polymers had an extremely high binding capacity and selectivity, and thus a super-high imprinting factor was obtained. The as-prepared imprinted polymers were used to separate the template lysozyme from egg white successfully, indicating its high selectivity and potential application in the field of separation of protein from real samples.
语种英语
WOS记录号WOS:000325482500020
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137593
专题中国科学院大连化学物理研究所
作者单位1.Nankai Univ, Dept Chem, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Synerget Innovat Ctr Chem Sci & Engn Tianjin, Tianjin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Peoples R China
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GB/T 7714
Chen, Yang,He, Xi-Wen,Mao, Jie,et al. Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein[J]. JOURNAL OF SEPARATION SCIENCE,2013,36(20):3449-3456.
APA Chen, Yang,He, Xi-Wen,Mao, Jie,Li, Wen-You,&Zhang, Yu-Kui.(2013).Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein.JOURNAL OF SEPARATION SCIENCE,36(20),3449-3456.
MLA Chen, Yang,et al."Preparation and application of hollow molecularly imprinted polymers with a super-high selectivity to the template protein".JOURNAL OF SEPARATION SCIENCE 36.20(2013):3449-3456.
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