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Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry
Sui, Zhigang1,2; Li, Na2; Liu, Zhiqiang3; Yan, Jun1; Liu, Zhongying1
关键词Aconitine Fragmentation Pathway Lc/esi/msn Metabolites Stomach
刊名XENOBIOTICA
2013-07-01
DOI10.3109/00498254.2012.753490
43期:7页:628-635
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]HUMAN INTESTINAL BACTERIA ; TISSUE DISTRIBUTION ; MAIN METABOLITE ; ALKALOIDS ; RATS ; BIOTRANSFORMATION
英文摘要1. Aconitine (AC), an active and highly toxic constituent extracted from aconitum plants, is well known for its excellent effects against rheumatism and rheumatoid arthritis. The metabolism of AC in liver and intestine has been previously reported. However, little is known about the metabolism of AC in stomach. In this study, the metabolite profiling of AC in stomachs of rabbit and rat was performed by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry (LC/ESI/MSn), for the first time.
语种英语
WOS记录号WOS:000319881000007
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137609
专题中国科学院大连化学物理研究所
作者单位1.Jilin Univ, Coll Pharm, Changchun 130021, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
3.Chinese Acad Sci, Chang Chun Inst Appl Chem, Changchun, Peoples R China
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GB/T 7714
Sui, Zhigang,Li, Na,Liu, Zhiqiang,et al. Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry[J]. XENOBIOTICA,2013,43(7):628-635.
APA Sui, Zhigang,Li, Na,Liu, Zhiqiang,Yan, Jun,&Liu, Zhongying.(2013).Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry.XENOBIOTICA,43(7),628-635.
MLA Sui, Zhigang,et al."Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry".XENOBIOTICA 43.7(2013):628-635.
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