DICP OpenIR
Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis
Zheng, Wei1,2; Luo, Qun1,2; Lin, Yu1,2; Zhao, Yao1,2; Wang, Xiuli3; Du, Zhifeng1,2; Hao, Xiang1; Yu, Yang3; Lu, Shuang1,2; Ji, Liyun1,2; Li, Xianchan1,2; Yang, Ling3; Wang, Fuyi1,2
Source PublicationCHEMICAL COMMUNICATIONS
2013
DOI10.1039/c3cc43000f
Volume49Issue:87Pages:10224-10226
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordPOST-GENOMIC ERA ; ARENE COMPLEXES ; IN-VITRO ; KINASE INHIBITORS ; CELL CYTOTOXICITY ; ANTITUMOR DRUGS ; METAL-COMPLEXES ; CHEMICAL SPACE ; CANCER-CELLS ; BINDING
AbstractThe complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.
Language英语
WOS IDWOS:000325643500004
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/137627
Collection中国科学院大连化学物理研究所
Affiliation1.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Wei,Luo, Qun,Lin, Yu,et al. Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis[J]. CHEMICAL COMMUNICATIONS,2013,49(87):10224-10226.
APA Zheng, Wei.,Luo, Qun.,Lin, Yu.,Zhao, Yao.,Wang, Xiuli.,...&Wang, Fuyi.(2013).Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis.CHEMICAL COMMUNICATIONS,49(87),10224-10226.
MLA Zheng, Wei,et al."Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis".CHEMICAL COMMUNICATIONS 49.87(2013):10224-10226.
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