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题名: Fast Equilibrium Micro-Extraction from Biological Fluids with Biocompatible Core-Sheath Electrospun Nanofibers
作者: Wu, Qian1, 2;  Wu, Dapeng1;  Guan, Yafeng1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2013-06-18
DOI: 10.1021/ac4006974
卷: 85, 期:12, 页:5924-5932
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Sample preparation methods with high temporal resolution and matrix resistance will benefit fast direct analysis of analytes in a complex matrix, such as drug monitoring in biofluids. In this work, the core-sheath biocompatible electrospun nanofiber was fabricated as a micro-solid phase extraction material. With the poly(N-isopropylacrylamide) (PNIPAAm) as sheath polymer and polystyrene (PS) as core polymer, the fiber membrane was highly hydrophilic and exhibited good antifouling ability to proteins and cells. Its complete expansion in aqueous solution and its nanoscale fiber (100-200 nm) structure offered high mass transfer rate of analytes between liquid and solid phases. The equilibration time of microextraction with this membrane was all shorter than 2 min for eight drugs tested, and the linear ranges covered more than 3 orders of magnitude for most of them. This membrane could be applied to monitor free drugs in plasma and their protein binding kinetics by equilibrium-microextraction with a 2 min temporal resolution. The results showed that the core-sheath electrospun nanofiber membrane would be a better alternative of solid phase material for microextraction with good matrix-resistance ability and high temporal resolution.
关键词[WOS]: SOLID-PHASE MICROEXTRACTION ;  PLASMA-PROTEIN BINDING ;  LIQUID-CHROMATOGRAPHY ;  POLYMER NANOFIBERS ;  WETTABILITY ;  ADSORPTION ;  SAMPLES ;  FIBER ;  POLY(N-ISOPROPYLACRYLAMIDE) ;  SURFACES
语种: 英语
WOS记录号: WOS:000320749200044
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137630
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dept Instrumentat & Analyt Chem, Key Lab Separat Sci Analyt Chem CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Wu, Qian,Wu, Dapeng,Guan, Yafeng. Fast Equilibrium Micro-Extraction from Biological Fluids with Biocompatible Core-Sheath Electrospun Nanofibers[J]. ANALYTICAL CHEMISTRY,2013,85(12):5924-5932.
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