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Study of the peak variance in isocratic and gradient liquid chromatography using the transport model
Hao, Weiqiang1; Di, Bin2; Chen, Qiang1; Wang, Junde3; Yang, Yongbin1; Sun, Xiaoli1
关键词Gradient Elution Liquid Chromatography Transport Model Plate Height
刊名JOURNAL OF CHROMATOGRAPHY A
2013-06-21
DOI10.1016/j.chroma.2013.04.044
1295页:67-81
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MASS-TRANSFER KINETICS ; ELUTION CHROMATOGRAPHY ; ION-EXCHANGE ; COMPRESSION FACTOR ; FRONTAL ANALYSIS ; LINEAR GRADIENT ; IDEAL MODEL ; PHASE ; SEPARATIONS ; PROTEINS
英文摘要The expressions accounting for the peak variance in isocratic and gradient liquid chromatography is derived from the transport model. In mathematical treatments, the dwelling time is taken into account, and the type of solvent strength, gradient profile and the variation of plate height (H) with mobile phase composition (phi) is not specified. By applying a coordinate transformation, the transport model is solved by using the Laplace transform approach. A plate height equation that is suited for both isocratic and gradient elution is obtained. Based on this equation, the plate height equations for any combination of stepwise and linear gradients are derived. These equations will be algebraic when the solvent strength is linear and the H-phi plot is parabolic. The plate height equations for single stepwise, single linear and the ladder-like gradients are also given. (C) 2013 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000320294000007
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137666
专题中国科学院大连化学物理研究所
作者单位1.Nanjing Univ, High Tech Res Inst, Changzhou 213164, Peoples R China
2.China Pharmaceut Univ, Dept Pharmaceut Anal, Nanjing 210009, Jiangsu, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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GB/T 7714
Hao, Weiqiang,Di, Bin,Chen, Qiang,et al. Study of the peak variance in isocratic and gradient liquid chromatography using the transport model[J]. JOURNAL OF CHROMATOGRAPHY A,2013,1295:67-81.
APA Hao, Weiqiang,Di, Bin,Chen, Qiang,Wang, Junde,Yang, Yongbin,&Sun, Xiaoli.(2013).Study of the peak variance in isocratic and gradient liquid chromatography using the transport model.JOURNAL OF CHROMATOGRAPHY A,1295,67-81.
MLA Hao, Weiqiang,et al."Study of the peak variance in isocratic and gradient liquid chromatography using the transport model".JOURNAL OF CHROMATOGRAPHY A 1295(2013):67-81.
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