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A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities
Jiao, Wence1; Zhang, Fenghua2; Zhao, Xinqing1; Hu, Jiehan3; Suh, Joo-Won4
Source PublicationPLOS ONE
2013-10-01
DOI10.1371/journal.pone.0075994
Volume8Issue:10
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordACINETOBACTER-BAUMANNII ; SALINISPORA-TROPICA ; NATURAL-PRODUCTS ; CHIRAL SULFUR ; SP NOV. ; SULFOXIDE ; METABOLITES ; ANTIBIOTICS ; CHEMISTRY ; DISCOVERY
AbstractDue to the increasing emergence of drug-resistant bacteria and tumor cell lines, novel antibiotics with antibacterial and cytotoxic activities are urgently needed. Marine actinobacteria are rich sources of novel antibiotics, and here we report the discovery of a novel alkaloid, xinghaiamine A, from a marine-derived actinomycete Streptomyces xinghaiensis NRRL B24674(T). Xinghaiamine A was purified from the fermentation broth, and its structure was elucidated based on extensive spectroscopic analysis, including 1D and 2D NMR spectrum as well as mass spectrometry. Xinghaiamine A was identified to be a novel alkaloid with highly symmetric structure on the basis of sulfoxide functional group, and sulfoxide containing compound has so far never been reported in microorganisms. Biological assays revealed that xinghaiamine A exhibited broad-spectrum antibacterial activities to both Gram-negative persistent hospital pathogens (e. g. Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli) and Gram-positive ones, which include Staphylococcus aureus and Bacillus subtilis. In addition, xinghaiamine A also exhibited potent cytotoxic activity to human cancer cell lines of MCF-7 and U-937 with the IC50 of 0.6 and 0.5 mu M, respectively.
Language英语
WOS IDWOS:000325427100033
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/137672
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
4.Myongji Univ, Div Biosci & Bioinformat, Yongin, South Korea
Recommended Citation
GB/T 7714
Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,et al. A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities[J]. PLOS ONE,2013,8(10).
APA Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,Hu, Jiehan,&Suh, Joo-Won.(2013).A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities.PLOS ONE,8(10).
MLA Jiao, Wence,et al."A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities".PLOS ONE 8.10(2013).
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