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A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities
Jiao, Wence1; Zhang, Fenghua2; Zhao, Xinqing1; Hu, Jiehan3; Suh, Joo-Won4
刊名PLOS ONE
2013-10-01
DOI10.1371/journal.pone.0075994
8期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ACINETOBACTER-BAUMANNII ; SALINISPORA-TROPICA ; NATURAL-PRODUCTS ; CHIRAL SULFUR ; SP NOV. ; SULFOXIDE ; METABOLITES ; ANTIBIOTICS ; CHEMISTRY ; DISCOVERY
英文摘要Due to the increasing emergence of drug-resistant bacteria and tumor cell lines, novel antibiotics with antibacterial and cytotoxic activities are urgently needed. Marine actinobacteria are rich sources of novel antibiotics, and here we report the discovery of a novel alkaloid, xinghaiamine A, from a marine-derived actinomycete Streptomyces xinghaiensis NRRL B24674(T). Xinghaiamine A was purified from the fermentation broth, and its structure was elucidated based on extensive spectroscopic analysis, including 1D and 2D NMR spectrum as well as mass spectrometry. Xinghaiamine A was identified to be a novel alkaloid with highly symmetric structure on the basis of sulfoxide functional group, and sulfoxide containing compound has so far never been reported in microorganisms. Biological assays revealed that xinghaiamine A exhibited broad-spectrum antibacterial activities to both Gram-negative persistent hospital pathogens (e. g. Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli) and Gram-positive ones, which include Staphylococcus aureus and Bacillus subtilis. In addition, xinghaiamine A also exhibited potent cytotoxic activity to human cancer cell lines of MCF-7 and U-937 with the IC50 of 0.6 and 0.5 mu M, respectively.
语种英语
WOS记录号WOS:000325427100033
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137672
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
4.Myongji Univ, Div Biosci & Bioinformat, Yongin, South Korea
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Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,et al. A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities[J]. PLOS ONE,2013,8(10).
APA Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,Hu, Jiehan,&Suh, Joo-Won.(2013).A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities.PLOS ONE,8(10).
MLA Jiao, Wence,et al."A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities".PLOS ONE 8.10(2013).
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