中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities
作者: Jiao, Wence1;  Zhang, Fenghua2;  Zhao, Xinqing1;  Hu, Jiehan3;  Suh, Joo-Won4
刊名: PLOS ONE
发表日期: 2013-10-01
DOI: 10.1371/journal.pone.0075994
卷: 8, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Due to the increasing emergence of drug-resistant bacteria and tumor cell lines, novel antibiotics with antibacterial and cytotoxic activities are urgently needed. Marine actinobacteria are rich sources of novel antibiotics, and here we report the discovery of a novel alkaloid, xinghaiamine A, from a marine-derived actinomycete Streptomyces xinghaiensis NRRL B24674(T). Xinghaiamine A was purified from the fermentation broth, and its structure was elucidated based on extensive spectroscopic analysis, including 1D and 2D NMR spectrum as well as mass spectrometry. Xinghaiamine A was identified to be a novel alkaloid with highly symmetric structure on the basis of sulfoxide functional group, and sulfoxide containing compound has so far never been reported in microorganisms. Biological assays revealed that xinghaiamine A exhibited broad-spectrum antibacterial activities to both Gram-negative persistent hospital pathogens (e. g. Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli) and Gram-positive ones, which include Staphylococcus aureus and Bacillus subtilis. In addition, xinghaiamine A also exhibited potent cytotoxic activity to human cancer cell lines of MCF-7 and U-937 with the IC50 of 0.6 and 0.5 mu M, respectively.
关键词[WOS]: ACINETOBACTER-BAUMANNII ;  SALINISPORA-TROPICA ;  NATURAL-PRODUCTS ;  CHIRAL SULFUR ;  SP NOV. ;  SULFOXIDE ;  METABOLITES ;  ANTIBIOTICS ;  CHEMISTRY ;  DISCOVERY
语种: 英语
WOS记录号: WOS:000325427100033
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137672
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
4.Myongji Univ, Div Biosci & Bioinformat, Yongin, South Korea

Recommended Citation:
Jiao, Wence,Zhang, Fenghua,Zhao, Xinqing,et al. A Novel Alkaloid from Marine-Derived Actinomycete Streptomyces xinghaiensis with Broad-Spectrum Antibacterial and Cytotoxic Activities[J]. PLOS ONE,2013,8(10).
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Jiao, Wence]'s Articles
 [Zhang, Fenghua]'s Articles
 [Zhao, Xinqing]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Jiao, Wence]‘s Articles
 [Zhang, Fenghua]‘s Articles
 [Zhao, Xinqing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace