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题名: A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications
作者: Ge, Guang-Bo1;  Ning, Jing1, 2;  Hu, Liang-Hai3;  Dai, Zi-Ru1;  Hou, Jie2;  Cao, Yun-Feng1;  Yu, Zhen-Wen1;  Ai, Chun-Zhi1;  Gu, Jing-Kai3;  Ma, Xiao-Chi2;  Yang, Ling1
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2013
DOI: 10.1039/c3cc45250f
卷: 49, 期:84, 页:9779-9781
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Bufalin 5 beta-hydroxylation was found to be an isoform-specific biotransformation probe substrate for cytochrome P450 3A4 (CYP3A4). The probe reaction was well-characterized and it can be used for measuring the real catalytic activities of CYP3A4 from different enzyme sources.
关键词[WOS]: IN-VITRO ;  CYP3A5 ;  INHIBITION ;  METABOLISM ;  MECHANISM ;  POLYMORPHISMS ;  EXPRESSION ;  DRUGS
语种: 英语
WOS记录号: WOS:000324928000022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137709
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Dalian Med Univ, Dalian, Peoples R China
3.Jilin Univ, Res Ctr Drug Metab, Coll Life Sci, Changchun 130023, Peoples R China

Recommended Citation:
Ge, Guang-Bo,Ning, Jing,Hu, Liang-Hai,et al. A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications[J]. CHEMICAL COMMUNICATIONS,2013,49(84):9779-9781.
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