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题名: Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships
作者: Yuan, Xiaoyan1, 2;  Cheng, Mengchun1;  Gao, Mingzhe1;  Zhuo, Rongjie1;  Zhang, Liangxiao1;  Xiao, Hongbin1
关键词: Helianthus tuberosus L. ;  Cytotoxic activity ;  Sesquiterpene lactones ;  Structure-activity relationship
刊名: PHYTOCHEMISTRY LETTERS
发表日期: 2013-02-01
DOI: 10.1016/j.phytol.2012.10.007
卷: 6, 期:1, 页:21-25
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ;  Plant Sciences
英文摘要: Bioassay-directed phytochemical study of the Jerusalem artichoke (Helianthus tuberosus L.) leaves led to the isolation of a new sesquiterpene lactone of 3-Hydroxy-8 beta-tigloyloxy-1,10-dehydroariglovin (1), ten known sesquiterpene lactones (2-11) and two known flavones (12-13). Their chemical structures were elucidated on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The cytotoxic activities of those compounds were subsequently tested against the MCF-7, A549 and HeLa cancer cells lines. The results indicated that sesquiterpene lactones 1-11 exhibited consistent cytotoxicity against all three cancer cell lines, while flavones 12 and 13 showed selective inhibitory activity against HeLa cell lines. Among them, compound 3 exhibited significant growth inhibitory activity against all three cell lines. The IC50 values of compound 3 against MCF-7, A549 and HeLa were 1.97 +/- 0.04, 7.79 +/- 0.44, 9.87 +/- 0.20 mu g/ml, respectively. In addition, some structure-activity relationships of these sesquiterpene lactones for cytotoxicity were explored and summarized in this study. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
关键词[WOS]: SESQUITERPENE LACTONES
语种: 英语
WOS记录号: WOS:000314477900006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137712
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Zunyi Med Coll, Sch Pharm, Zunyi 563000, Peoples R China

Recommended Citation:
Yuan, Xiaoyan,Cheng, Mengchun,Gao, Mingzhe,et al. Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships[J]. PHYTOCHEMISTRY LETTERS,2013,6(1):21-25.
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