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Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships
Yuan, Xiaoyan1,2; Cheng, Mengchun1; Gao, Mingzhe1; Zhuo, Rongjie1; Zhang, Liangxiao1; Xiao, Hongbin1
关键词HeL.anthus Tuberosus L. Cytotoxic Activity Sesquiterpene Lactones Structure-activity Relationship
刊名PHYTOCHEMISTRY LETTERS
2013-02-01
DOI10.1016/j.phytol.2012.10.007
6期:1页:21-25
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]SESQUITERPENE LACTONES
英文摘要Bioassay-directed phytochemical study of the Jerusalem artichoke (Helianthus tuberosus L.) leaves led to the isolation of a new sesquiterpene lactone of 3-Hydroxy-8 beta-tigloyloxy-1,10-dehydroariglovin (1), ten known sesquiterpene lactones (2-11) and two known flavones (12-13). Their chemical structures were elucidated on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The cytotoxic activities of those compounds were subsequently tested against the MCF-7, A549 and HeLa cancer cells lines. The results indicated that sesquiterpene lactones 1-11 exhibited consistent cytotoxicity against all three cancer cell lines, while flavones 12 and 13 showed selective inhibitory activity against HeLa cell lines. Among them, compound 3 exhibited significant growth inhibitory activity against all three cell lines. The IC50 values of compound 3 against MCF-7, A549 and HeLa were 1.97 +/- 0.04, 7.79 +/- 0.44, 9.87 +/- 0.20 mu g/ml, respectively. In addition, some structure-activity relationships of these sesquiterpene lactones for cytotoxicity were explored and summarized in this study. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
语种英语
WOS记录号WOS:000314477900006
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137712
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Zunyi Med Coll, Sch Pharm, Zunyi 563000, Peoples R China
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Yuan, Xiaoyan,Cheng, Mengchun,Gao, Mingzhe,et al. Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships[J]. PHYTOCHEMISTRY LETTERS,2013,6(1):21-25.
APA Yuan, Xiaoyan,Cheng, Mengchun,Gao, Mingzhe,Zhuo, Rongjie,Zhang, Liangxiao,&Xiao, Hongbin.(2013).Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships.PHYTOCHEMISTRY LETTERS,6(1),21-25.
MLA Yuan, Xiaoyan,et al."Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure-activity relationships".PHYTOCHEMISTRY LETTERS 6.1(2013):21-25.
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