中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation
作者: Cong, Ming1;  Hu, Cui-Min5;  Cao, Yun-Feng2, 3;  Fang, Zhong-Ze2, 3, 5;  Tang, Shu-Hong4;  Wang, Jia-Rui4;  Luo, Jun-Sheng1
关键词: Danshen ;  UDP-glucuronosyltransferases (UGTs) ;  Herb-drug interaction
刊名: FITOTERAPIA
发表日期: 2013-03-01
DOI: 10.1016/j.fitote.2013.01.002
卷: 85, 页:109-113
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Danshen is one of the most famous herbs in the world, and more and more danshen-prescribed drugs interactions have been reported in recent years. Evaluation of inhibition potential of danshen's major ingredients towards UDP-glucuronosyltransferases (UGTs) will be helpful for understanding detailed mechanisms for danshen-drugs interaction. Therefore, the aim of the present study is to investigate the inhibitory situation of cryptotanshinone and dihydrotanshinone I towards UGT enzyme-catalyzed propofol glucuronidation. In vitro the human liver microsome (HLM) incubation system was used, and the results showed that cryptotanshinone and dihydrotanshinone I exhibited dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dixon plot and Lineweaver-Burk plot showed that the inhibition type was best fit to competitive inhibition type for both cryptotanshinone and dihydrotanshinone I. The second plot using the slopes from the Lineweaver-Burk plot versus the concentrations of cryptotanshinone or dihydrotanshinone I was employed to calculate the inhibition parameters (K-1) to be 0.4 and 1.7 mu M, respectively. Using the reported maximum plasma concentration (C-max), the altered in vivo exposure of propofol increased by 10% and 8.2% for the co-administration of dihydrotanshinone I and cryptotanshinone, respectively. All these results indicated the possible danshen-propofol interaction due to the inhibition of dihydrotanshinone I and cryptotanshinone towards the glucuronidation reaction of propofol. (C) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: UDP-GLUCURONOSYLTRANSFERASE ISOFORMS ;  SALVIA-MILTIORRHIZA ;  SUPRAVENTRICULAR TACHYCARDIA ;  TANSHINONE IIA ;  IDENTIFICATION ;  CONSTITUENTS ;  CHEMISTRY
语种: 英语
WOS记录号: WOS:000317172000016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137738
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116023, Peoples R China
3.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China
4.Fifth Hosp Dalian, Dept Oncol, Dalian 116021, Peoples R China
5.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA

Recommended Citation:
Cong, Ming,Hu, Cui-Min,Cao, Yun-Feng,et al. Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation[J]. FITOTERAPIA,2013,85:109-113.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Cong, Ming]'s Articles
 [Hu, Cui-Min]'s Articles
 [Cao, Yun-Feng]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Cong, Ming]‘s Articles
 [Hu, Cui-Min]‘s Articles
 [Cao, Yun-Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace