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题名: Crotonaldehyde induces apoptosis and immunosuppression in alveolar macrophages
作者: Yang, Bi-cheng1, 2;  Yang, Zhi-hua3;  Pan, Xiu-jie3;  Liu, Xing-yu4;  Zhu, Mao-xiang3;  Xie, Jian-ping2
关键词: Crotonaldehyde ;  Apoptosis ;  Immunosuppression ;  Alveolar macrophages
刊名: TOXICOLOGY IN VITRO
发表日期: 2013-02-01
DOI: 10.1016/j.tiv.2012.09.008
卷: 27, 期:1, 页:128-137
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
英文摘要: Crotonaldehyde, a highly toxic alpha, beta-unsaturated aldehyde, is a major component of cigarette smoke (CS) and a ubiquitous environmental pollutant. Exposure to crotonaldehyde-rich pollutants such as CS is associated with suppression of respiratory host defense against infections. The aim of this study was to evaluate the apoptotic and immunological effects of crotonaldehyde exposure in a rat alveolar macrophage (AM) cell line, NR8383. Our studies showed that crotonaldehyde induced AM cell death mainly via the apoptotic process. Crotonaldehyde also decreased the phagocytic activity of AMs. Crotonaldehyde caused inhibition of NO, TNF-alpha, IL-1 beta and IL-12 production in AMs treated with lipopolysaccharide (LPS), which is probably related to inhibition of NF-kappa B activation. These results indicate that crotonaldehyde can cause adverse effects in AMs via multiple mechanisms, and may contribute to compromised lung immunological response in smokers. (C) 2012 Elsevier Ltd. All rights reserved.
关键词[WOS]: NF-KAPPA-B ;  BRONCHIAL EPITHELIAL-CELLS ;  FLUORESCENT LATEX BEADS ;  CIGARETTE-SMOKE ;  OXIDATIVE STRESS ;  INFLAMMATORY RESPONSE ;  GAS-CHROMATOGRAPHY ;  MASS-SPECTROMETRY ;  LUNG MACROPHAGES ;  GENE-EXPRESSION
语种: 英语
WOS记录号: WOS:000314371600016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137753
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Zhengzhou Tobacco Res Inst CNTC, Zhengzhou 450001, Henan, Peoples R China
3.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China
4.Shanghai Tobacco Corp, Ctr Technol, Beijing Work Stn, Beijing 101121, Peoples R China

Recommended Citation:
Yang, Bi-cheng,Yang, Zhi-hua,Pan, Xiu-jie,et al. Crotonaldehyde induces apoptosis and immunosuppression in alveolar macrophages[J]. TOXICOLOGY IN VITRO,2013,27(1):128-137.
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