中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms
作者: Guo, Bin1;  Fan, Xu-Ran2, 3;  Fang, Zhong-Ze2, 3, 5;  Cao, Yun-Feng2, 3;  Hu, Cui-Min5;  Yang, Julin6;  Zhang, Yan-Yan2, 3;  He, Rong-Rong4;  Zhu, Xu2, 3;  Yu, Zhen-Wen2, 3;  Sun, Xiao-Yu2, 3;  Hong, Mo2, 3;  Yang, Lu2, 3
关键词: UDP-glucuronosyltransferase ;  licorice ;  liquiritin ;  liquiritigenin
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2013-08-01
DOI: 10.1002/ptr.4855
卷: 27, 期:8, 页:1232-1236
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: The detailed mechanisms on licorice-drug interaction remain to be unclear. The aim of the present study is to investigate the inhibition of important UGT isoforms by two important ingredients of licorice, liquiritin, and liquiritigenin. The results showed that liquiritigenin exhibited stronger inhibition towards all the tested UGT isoforms than liquiritin. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the competitive inhibition of liquiritigenin towards UGT1A1 and UGT1A9-mediated 4-MU glucuronidation reaction. The inhibition kinetic parameters (K-i) were calculated to be 9.1 and 3.2M for UGT1A1 and UGT1A9, respectively. Substrate-dependent inhibition behaviour was also observed for UGT1A1 in the present study. All these results will be helpful for understanding the deep mechanism of licorice-drug interaction. However, when translating these in vitro parameters into in vivo situations, more complex factors should be considered, such as substrate-dependent inhibition of UGT isoforms, the contribution of UGT1A1 and UGT1A9 towards the metabolism of drugs, and many factors affecting the abundance of ingredients in the licorice. Copyright (c) 2012 John Wiley & Sons, Ltd.
关键词[WOS]: DRUG-DRUG INTERACTIONS
语种: 英语
WOS记录号: WOS:000322114900019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137786
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116023, Peoples R China
3.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China
4.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
5.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA
6.Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China

Recommended Citation:
Guo, Bin,Fan, Xu-Ran,Fang, Zhong-Ze,et al. Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms[J]. PHYTOTHERAPY RESEARCH,2013,27(8):1232-1236.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Guo, Bin]'s Articles
 [Fan, Xu-Ran]'s Articles
 [Fang, Zhong-Ze]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Guo, Bin]‘s Articles
 [Fan, Xu-Ran]‘s Articles
 [Fang, Zhong-Ze]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace