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题名: Femtosecond Laser-Induced Micropattern and Ca/P Deposition on Ti Implant Surface and Its Acceleration on Early Osseointegration
作者: Liang, Chunyong1;  Wang, Hongshui1;  Yang, Jianjun2;  Cai, Yanli1, 3;  Hu, Xin4;  Yang, Yang2, 5;  Li, Baoe1;  Li, Hongjie4;  Li, Haipeng1;  Li, Changyi4;  Yang, Xianjin3
关键词: femtosecond lasers ;  Ti implant ;  Ca/P phase ;  micropatterning ;  osseointegration
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2013-08-28
DOI: 10.1021/am402290e
卷: 5, 期:16, 页:8179-8186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ;  Materials Science
英文摘要: Surface microstructure and chemical composition of the implant are very important for its osseointegration in vivo. In this paper, a hierarchical micropattern covered with calcium phosphate (Ca/P phase) was obtained on titanium (Ti) implant surface by femtosecond lasers (FSL) irradiation in hydroxyapatite suspension. The hierachical micropattern as well as Ca/P phase increased osteoblastic cell adhesion. Higher expression of osteogenic markers (osteocalcin, osteopontin, and runt related transcription factor-2) on the surface treated by FSL of 2.55 J/cm(2) indicated the favorable effect of laser treatment on cell differentiation. In vivo studies were carried out to evaluate the effect of laser treatment and Ca/P deposition on the osseointegration. It showed that the binding capacity between bone and FSL-treated Ti implants was obviously stronger than that between bone and polished or sand blasting and acid etching (SLA) Ti implants. Bone trabecula surrounded the FSL-treated implants without fibrous tissue after 8-week implantation. Also, higher bone mineral density was seen surrounding the FSL-treated implants. Our in vitro and in vivo studies demonstrated that the FSL induced micropattern and Ca/P phase had positive effects on the acceleration of early osseointegration of Ti implants with bone tissue.
关键词[WOS]: TITANIUM IMPLANTS ;  NITI ALLOY ;  IN-VIVO ;  PULSES ;  OSTEOINTEGRATION ;  MICROSTRUCTURES ;  INTEGRATION ;  SUBSTRATE ;  ABLATION ;  SILICON
语种: 英语
WOS记录号: WOS:000323875800075
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137810
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China
2.Nankai Univ, Inst Modern Opt, Tianjin 300071, Peoples R China
3.Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China
4.Tianjin Med Univ, Stomatol Hosp, Tianjin 300070, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China

Recommended Citation:
Liang, Chunyong,Wang, Hongshui,Yang, Jianjun,et al. Femtosecond Laser-Induced Micropattern and Ca/P Deposition on Ti Implant Surface and Its Acceleration on Early Osseointegration[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(16):8179-8186.
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