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题名: Rapid simultaneous quantitative determination of terpenoids in Tripterygium wilfordii Hook F by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
作者: Zhuo, Rongjie1;  Zhang, Liangxiao1;  Wang, Li1;  Shan, Guoshun1, 2;  Yang, Qianxu1;  Yuan, Xiaoyan1;  Xiao, Hongbin1
刊名: ANALYTICAL METHODS
发表日期: 2013
DOI: 10.1039/c3ay26501c
卷: 5, 期:8, 页:2046-2052
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine ;  Technology
类目[WOS]: Chemistry, Analytical ;  Food Science & Technology ;  Spectroscopy
研究领域[WOS]: Chemistry ;  Food Science & Technology ;  Spectroscopy
英文摘要: A rapid and sensitive method for simultaneous quantitative determination of terpenoids in Tripterygium wilfordii Hook F (TwHF) was developed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). In this method, five major terpenoids, including triptolide, triptonide, demethylzelastral, tripterine and wilforlide A, with large content range in TwHF, were determined simultaneously in a UHPLC run of 4.5 minutes. The intra-day and inter-day precisions of five terpenoids were less than 4.58% and 4.82%, respectively, and the mean recovery rates obtained were in the range of 97.2% to 104.5%. All calibration curves showed good linearity (r(2) > 0.996) from 20 ng mL(-1) and 20 000 ng mL(-1). The limit of detection (LOD) and limit of quantitation (LOQ) were less than 5.7 ng mL(-1) and 19.0 ng mL(-1). Compared with previous studies, this method could be employed for accurate quantification of five terpenoids in different parts and products of TwHF in a very short time after simple ultrasonic extraction. The results indicated that this method would provide a rapid and sensitive way for evaluating the quality of the TwHF and its products.
关键词[WOS]: SOLID-PHASE EXTRACTION ;  ROOT EXTRACTS ;  TRIPTOLIDE ;  TRIPDIOLIDE ;  ALKALOIDS ;  TRIPTONIDE ;  TRIPTERINE ;  LEAVES
语种: 英语
WOS记录号: WOS:000316960200022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137820
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Liaoning Univ TCM, Sch Pharm, Dalian 116600, Peoples R China

Recommended Citation:
Zhuo, Rongjie,Zhang, Liangxiao,Wang, Li,et al. Rapid simultaneous quantitative determination of terpenoids in Tripterygium wilfordii Hook F by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry[J]. ANALYTICAL METHODS,2013,5(8):2046-2052.
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