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题名: Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry
作者: Zeng, Jun1;  Kuang, Hua2, 3;  Hu, Chunxiu1;  Shi, Xianzhe1;  Yan, Min1;  Xu, Liguang2, 3;  Wang, Libing2, 3;  Xu, Chuanlai2, 3;  Xu, Guowang1
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2013-07-02
DOI: 10.1021/es400490f
卷: 47, 期:13, 页:7457-7465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology ;  Life Sciences & Biomedicine
类目[WOS]: Engineering, Environmental ;  Environmental Sciences
研究领域[WOS]: Engineering ;  Environmental Sciences & Ecology
英文摘要: Bisphenol A (BPA), a chemical widely used in the manufacture of polycarbonate plastics, has raised considerable concern in recent decades because of its hormone-like properties. Whether BPA exposure is a health risk remains controversial in many countries. A metabolomics study based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS) was performed to study the urine metabolic profiles of Sprague Dawley rats fed with four dose levels of BPA (0, 1, 10, and 100 mu g/kg body weight) for 45 days. Multivariate pattern recognition directly reflected the metabolic perturbations caused by BPA. On the basis of univariate analysis, 42 metabolites including amino acids, polyammes, nucleosides, organic acids, carbohydrates, pterins, polyphenols, and sugar phosphates were found as the most significantly differential metabolites. The marked perturbations were related with valine, leucine and isoleucine biosynthesis, D-glutamine and D-glutamate metabolism, etc. Significant alterations of neurotransmitters (glutamate, gamma-aminobutyric acid, and noradrenaline) and neurotransmitter-related metabolites (tyrosine, histamine, valine, and taurine) suggested that the toxic effects of small-dose BPA (below 50 mg/kg/day) may contribute to its interactions with the neuromediating system. Our study demonstrated that metabolomics may offer more specific insights into the molecular changes underlying the physiological effects of BPA.
关键词[WOS]: 2-GENERATION REPRODUCTIVE TOXICITY ;  FALSE DISCOVERY RATES ;  OXIDATIVE STRESS ;  DEVELOPMENTAL EXPOSURE ;  URINE ;  MICE ;  BRAIN ;  MEMORY ;  NEUROTRANSMISSION ;  HIPPOCAMPUS
语种: 英语
WOS记录号: WOS:000321521400089
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137841
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
3.Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

Recommended Citation:
Zeng, Jun,Kuang, Hua,Hu, Chunxiu,et al. Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2013,47(13):7457-7465.
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