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题名: Silencing the EZH2 gene by RNA interference reverses the drug resistance of human hepatic multidrug-resistant cancer cells to 5-Fu
作者: Zhang, Yi1;  Liu, Guangpu2;  Lin, Changwei3;  Liao, Guoqing1;  Tang, Bo4, 5
关键词: EZH2 ;  Hepatocellular carcinoma ;  Multidrug resistance ;  MDR1 ;  RNA interference
刊名: LIFE SCIENCES
发表日期: 2013-05-20
DOI: 10.1016/j.lfs.2013.03.010
卷: 92, 期:17-19, 页:896-902
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, Research & Experimental ;  Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ;  Pharmacology & Pharmacy
英文摘要: Aims: The EZH2 gene, which is expressed in various solid tumours, including liver cancer, can regulate gene transcription and promote the generation and progression of tumours. Our aim was to investigate the relationship between EZH2 and multidrug-resistance of human hepatic cancer cells using RNA interference.
关键词[WOS]: GROUP PROTEIN EZH2 ;  IN-VITRO ;  HEPATOCELLULAR-CARCINOMA ;  DNA METHYLATION ;  PROSTATE-CANCER ;  CONTRIBUTES ;  COMBINATION ;  PROGRESSION ;  PATHWAY ;  ALPHA
语种: 英语
WOS记录号: WOS:000318458400004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137861
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp, Dept Gastrointestinal Surg, Changsha 410008, Hunan, Peoples R China
2.Xuzhou Cent Hosp, Xuzhou 221000, Peoples R China
3.Cent S Univ, Xiangya Hosp 3, Dept Gastrointestinal Surg, Changsha 410013, Hunan, Peoples R China
4.Guilin Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Guilin 541000, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Beijing 116027, Peoples R China

Recommended Citation:
Zhang, Yi,Liu, Guangpu,Lin, Changwei,et al. Silencing the EZH2 gene by RNA interference reverses the drug resistance of human hepatic multidrug-resistant cancer cells to 5-Fu[J]. LIFE SCIENCES,2013,92(17-19):896-902.
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