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题名: Characterization of protoberberine alkaloids in Coptidis Rhizoma (Huanglian) by HPLC with ESI-MS/MS
作者: Ren, Lingling1, 2;  Xue, Xingya1;  Liang, Xinmiao1
关键词: Coptidis Rhizoma ;  Chromatography retention parameters ;  ESI-MS ;  MS ;  Protoberberine alkaloid
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2013-04-01
DOI: 10.1002/jssc.201201002
卷: 36, 期:8, 页:1389-1396
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: This study aims to qualitatively analyze protoberberine alkaloids in crude extract of Coptidis Rhizoma using HPLC with ESI-MS/MS. Possible specific molecular weights of protoberberine alkaloids were firstly deduced according to literatures and were adopted to screen the alkaloids in the HPLC with ESI-MS of crude extract of Coptidis Rhizoma. As a result, 21 protoberberine alkaloids were found, including compounds of very low concentration and compounds coeluted in one peak. Among these, two compounds were positively identified and verified by comparison with standards. Ten of these compounds were first reported in this study for Coptidis Rhizoma. In addition, chromatographic retention parameters a and c of all compounds were obtained using their retention times under five gradient conditions and were applied to confirm the deduction about the structures of protoberberine alkaloids by tandem mass data.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  IONIZATION-MASS-SPECTROMETRY ;  EVODIA HERB COUPLE ;  CHINESE MEDICINE ;  CAPILLARY ELECTROPHORESIS ;  BERBERINE ;  PALMATINE ;  PLASMA ;  MS
语种: 英语
WOS记录号: WOS:000319866000009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137863
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Anhui Med Univ, Dept Publ Hlth, Hefei, Peoples R China

Recommended Citation:
Ren, Lingling,Xue, Xingya,Liang, Xinmiao. Characterization of protoberberine alkaloids in Coptidis Rhizoma (Huanglian) by HPLC with ESI-MS/MS[J]. JOURNAL OF SEPARATION SCIENCE,2013,36(8):1389-1396.
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