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题名: An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines
作者: Guo, Ran-Ning1;  Cai, Xian-Feng1;  Shi, Lei1;  Ye, Zhi-Shi1;  Chen, Mu-Wang1;  Zhou, Yong-Gui1
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2013
DOI: 10.1039/c3cc45341c
卷: 49, 期:76, 页:8537-8539
收录类别: SCI ;  IC ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: An efficient iridium-catalyzed asymmetric hydrogenation of the fluorinated isoquinoline derivatives has been successfully developed for the synthesis of chiral fluorinated tetrahydroisoquinoline derivatives with up to 93% ee. This methodology features the use of a hydrochloride salt as well as a catalytic amount of halogenated hydantoin which were vital for the reactivity, enantioselectivity, and inhibition of the hydrodefluorination pathway.
关键词[WOS]: IRIDIUM-CATALYZED HYDROGENATION ;  PHASE-TRANSFER CATALYST ;  BETA-X-ELIMINATION ;  BOND ACTIVATION ;  ENANTIOSELECTIVE HYDROGENATION ;  MEDICINAL CHEMISTRY ;  H IMINES ;  COMPLEXES ;  HYDRODEFLUORINATION ;  MECHANISM
语种: 英语
WOS记录号: WOS:000323726600035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137874
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Guo, Ran-Ning,Cai, Xian-Feng,Shi, Lei,et al. An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines[J]. CHEMICAL COMMUNICATIONS,2013,49(76):8537-8539.
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