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An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines
Guo, Ran-Ning; Cai, Xian-Feng; Shi, Lei; Ye, Zhi-Shi; Chen, Mu-Wang; Zhou, Yong-Gui
刊名CHEMICAL COMMUNICATIONS
2013
DOI10.1039/c3cc45341c
49期:76页:8537-8539
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]IRIDIUM-CATALYZED HYDROGENATION ; PHASE-TRANSFER CATALYST ; BETA-X-ELIMINATION ; BOND ACTIVATION ; ENANTIOSELECTIVE HYDROGENATION ; MEDICINAL CHEMISTRY ; H IMINES ; COMPLEXES ; HYDRODEFLUORINATION ; MECHANISM
英文摘要An efficient iridium-catalyzed asymmetric hydrogenation of the fluorinated isoquinoline derivatives has been successfully developed for the synthesis of chiral fluorinated tetrahydroisoquinoline derivatives with up to 93% ee. This methodology features the use of a hydrochloride salt as well as a catalytic amount of halogenated hydantoin which were vital for the reactivity, enantioselectivity, and inhibition of the hydrodefluorination pathway.
语种英语
WOS记录号WOS:000323726600035
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137874
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
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GB/T 7714
Guo, Ran-Ning,Cai, Xian-Feng,Shi, Lei,et al. An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines[J]. CHEMICAL COMMUNICATIONS,2013,49(76):8537-8539.
APA Guo, Ran-Ning,Cai, Xian-Feng,Shi, Lei,Ye, Zhi-Shi,Chen, Mu-Wang,&Zhou, Yong-Gui.(2013).An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines.CHEMICAL COMMUNICATIONS,49(76),8537-8539.
MLA Guo, Ran-Ning,et al."An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines".CHEMICAL COMMUNICATIONS 49.76(2013):8537-8539.
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