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题名: Proliferation, Sternness and Cardiac Differentiation Properties of Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells during the Continuous Passages
作者: Lv, Shi-jie1, 5;  Liu, Yang2;  Lian, Jian-chun3;  He, Xin3;  Liu, Chang2, 4;  Sun, Guang-wei2;  Guo, Xin2;  Ma, Xiao-jun2;  Li, Hui1
关键词: Cardiac differentiation ;  Continuous passage ;  Fetal mesenchymal stem cell ;  Stemness
刊名: JOURNAL OF HARD TISSUE BIOLOGY
发表日期: 2013-04-01
卷: 22, 期:2, 页:261-266
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical
研究领域[WOS]: Engineering
英文摘要: Fetal tissue-derived mesenchymal stem cells (MSCs) may offer greater clinical utility because they possess unique properties over bone marrow (BM) MSCs. Although the continuous passage process can generate numerous MSCs for clinical applications, this process may also have an important effect on the bological characteristics of fetal MSCs. In this study, the proliferation, sternness and cardiac differentiation properties of umbilical cord (UC) Wharton's Jelly-derived MSCs (WJ MSCs) at different passages (3, 7 and 14) was investigated. It was found that WJ MSC proliferation rate was decreased during the continuous passage process. And the ESC marker gene (Oct3/4, Nanog) expression in WJ MSCs also decreased gradually, while the early mesoderm marker gene (Vimentin) was highest at passage 7. Moreover, the cardiac marker gene (Nkx2.5) expression in differentiated MSCs increased during the continuous passage after cardiac induction. Our results may provide some useful information for stem cell therapy based on WJ MSCs.
关键词[WOS]: MYOCARDIAL-INFARCTION ;  BONE-MARROW
语种: 英语
WOS记录号: WOS:000318190200016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137896
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian, Peoples R China
3.Dalian Med Univ, Lab Med Coll, Dalian, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Dalian Matern Hosp, Dalian, Peoples R China

Recommended Citation:
Lv, Shi-jie,Liu, Yang,Lian, Jian-chun,et al. Proliferation, Sternness and Cardiac Differentiation Properties of Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells during the Continuous Passages[J]. JOURNAL OF HARD TISSUE BIOLOGY,2013,22(2):261-266.
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