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A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets
Liu, Jianling1; Pei, Mengjie1; Zheng, Chunli1; Li, Yan2; Wang, Yonghua3; Lu, Aiping4; Yang, Ling5
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/938764
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectIntegrative & Complementary Medicine
WOS Research AreaIntegrative & Complementary Medicine
WOS KeywordTRADITIONAL CHINESE MEDICINE ; MIGRATION INHIBITORY FACTOR ; ASTRAGALUS-MEMBRANACEUS ; CARDIOVASCULAR-DISEASE ; POLYGONUM-MULTIFLORUM ; PROGENITOR CELLS ; GROWTH-FACTORS ; NETWORK ; APOPTOSIS ; RECEPTOR
AbstractFor thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH and BTH was developed. It is indicated that QEH compounds have high lipophilicity while BTH compounds possess high chemical reactivity. Secondly, a systematic investigation integrating ADME (absorption, distribution, metabolism, and excretion) prediction, target fishing and network analysis was performed and validated on these herbs to obtain the compound-target associations for reconstructing the biologically-meaningful networks. The results suggest QEH enhance physical strength, immune system and normal well-being, acting as adjuvant therapy for chronic disorders while BTH stimulate hematopoiesis function in body. As an emerging approach, the systems pharmacology model might facilitate to understand the mechanisms of action of the tonic herbs, which brings about new development for complementary and alternative medicine.
Language英语
WOS IDWOS:000328026900001
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/137905
Collection中国科学院大连化学物理研究所
Affiliation1.Northwest Univ, Coll Life Sci, Xian 710000, Shaanxi, Peoples R China
2.Dalian Univ Technol, Dept Mat Sci & Chem Engn, Dalian 116000, Liaoning, Peoples R China
3.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yang Ling 712100, Shaanxi, Peoples R China
4.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong 999077, Hong Kong, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116000, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jianling,Pei, Mengjie,Zheng, Chunli,et al. A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Liu, Jianling.,Pei, Mengjie.,Zheng, Chunli.,Li, Yan.,Wang, Yonghua.,...&Yang, Ling.(2013).A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Liu, Jianling,et al."A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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