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A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets
Liu, Jianling1; Pei, Mengjie1; Zheng, Chunli1; Li, Yan2; Wang, Yonghua3; Lu, Aiping4; Yang, Ling5
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/938764
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]TRADITIONAL CHINESE MEDICINE ; MIGRATION INHIBITORY FACTOR ; ASTRAGALUS-MEMBRANACEUS ; CARDIOVASCULAR-DISEASE ; POLYGONUM-MULTIFLORUM ; PROGENITOR CELLS ; GROWTH-FACTORS ; NETWORK ; APOPTOSIS ; RECEPTOR
英文摘要For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH and BTH was developed. It is indicated that QEH compounds have high lipophilicity while BTH compounds possess high chemical reactivity. Secondly, a systematic investigation integrating ADME (absorption, distribution, metabolism, and excretion) prediction, target fishing and network analysis was performed and validated on these herbs to obtain the compound-target associations for reconstructing the biologically-meaningful networks. The results suggest QEH enhance physical strength, immune system and normal well-being, acting as adjuvant therapy for chronic disorders while BTH stimulate hematopoiesis function in body. As an emerging approach, the systems pharmacology model might facilitate to understand the mechanisms of action of the tonic herbs, which brings about new development for complementary and alternative medicine.
语种英语
WOS记录号WOS:000328026900001
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137905
专题中国科学院大连化学物理研究所
作者单位1.Northwest Univ, Coll Life Sci, Xian 710000, Shaanxi, Peoples R China
2.Dalian Univ Technol, Dept Mat Sci & Chem Engn, Dalian 116000, Liaoning, Peoples R China
3.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yang Ling 712100, Shaanxi, Peoples R China
4.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong 999077, Hong Kong, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116000, Liaoning, Peoples R China
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Liu, Jianling,Pei, Mengjie,Zheng, Chunli,et al. A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Liu, Jianling.,Pei, Mengjie.,Zheng, Chunli.,Li, Yan.,Wang, Yonghua.,...&Yang, Ling.(2013).A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Liu, Jianling,et al."A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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