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题名: Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway
作者: Wang, Cai-Ping1;  Li, Jian-Long1;  Zhang, Lu-Zhong1;  Zhang, Xiao-Chuan1;  Yu, Shu1;  Liang, Xin-Miao1, 2;  Ding, Fei1;  Wang, Zhi-Wei1, 3
关键词: Isoquercetin ;  Oxygen-glucose deprivation followed by reperfusion (OGD/R) ;  Ischemia ;  Apoptosis ;  Inflammation
刊名: NEUROCHEMISTRY INTERNATIONAL
发表日期: 2013-12-01
DOI: 10.1016/j.neuint.2013.09.018
卷: 63, 期:8, 页:741-749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ;  Neurosciences & Neurology
英文摘要: In the present study, oxygen-glucose deprivation followed by reperfusion (OGD/R), an in vitro model of ischemia, was used to evaluate the neuroprotective effect of isoquercetin in primary culture of rat cortical neuronal cells. It was found that isoquercetin administered prior to the insult could prevent OGD/R-induced intracellular calcium concentrations ([Ca2+](i)) increase, lactate dehydrogenase (LDH) release and cell viability decrease. For the first time, isoquercetin is described as a neuroprotective agent that potentially explains the alleviation and prevention from OGD/R-induced injury in neurons. Mechanistic studies showed that the neuroprotective effect of isoquercetin was carried out by anti-inflammatory signaling pathway of inhibiting protein expression of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappa B), and mRNA expression of TNF-alpha and IL-6, accompanied by the anti-apoptotic signaling pathway of deactivation of extracellular-regulated kinase (ERK), Jun kinase (JNK) and p38, and inhibition of activity of caspase-3. Therefore, these studies highlighted the confirmation of isoquercetin, a flavonoid compound, as an anti-inflammation and anti-apoptosis factor which might be used as a therapeutic strategy for the ischemia/reperfusion (I/R) brain injury and related diseases. (C) 2013 Elsevier Ltd. All rights reserved.
关键词[WOS]: FOCAL CEREBRAL-ISCHEMIA ;  TOLL-LIKE RECEPTOR-4 ;  NF-KAPPA-B ;  EXPERIMENTAL STROKE ;  BRAIN-INJURY ;  IN-VITRO ;  TERMINAL KINASE ;  MICE ;  CELLS ;  INFLAMMATION
语种: 英语
WOS记录号: WOS:000328872300004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137910
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA

Recommended Citation:
Wang, Cai-Ping,Li, Jian-Long,Zhang, Lu-Zhong,et al. Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway[J]. NEUROCHEMISTRY INTERNATIONAL,2013,63(8):741-749.
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