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Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway
Wang, Cai-Ping1; Li, Jian-Long1; Zhang, Lu-Zhong1; Zhang, Xiao-Chuan1; Yu, Shu1; Liang, Xin-Miao1,2; Ding, Fei1; Wang, Zhi-Wei1,3
KeywordIsoquercetin Oxygen-glucose Deprivation Followed By Reperfusion (Ogd/r) Ischemia Apoptosis Inflammation
Source PublicationNEUROCHEMISTRY INTERNATIONAL
2013-12-01
DOI10.1016/j.neuint.2013.09.018
Volume63Issue:8Pages:741-749
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology
WOS KeywordFOCAL CEREBRAL-ISCHEMIA ; TOLL-LIKE RECEPTOR-4 ; NF-KAPPA-B ; EXPERIMENTAL STROKE ; BRAIN-INJURY ; IN-VITRO ; TERMINAL KINASE ; MICE ; CELLS ; INFLAMMATION
AbstractIn the present study, oxygen-glucose deprivation followed by reperfusion (OGD/R), an in vitro model of ischemia, was used to evaluate the neuroprotective effect of isoquercetin in primary culture of rat cortical neuronal cells. It was found that isoquercetin administered prior to the insult could prevent OGD/R-induced intracellular calcium concentrations ([Ca2+](i)) increase, lactate dehydrogenase (LDH) release and cell viability decrease. For the first time, isoquercetin is described as a neuroprotective agent that potentially explains the alleviation and prevention from OGD/R-induced injury in neurons. Mechanistic studies showed that the neuroprotective effect of isoquercetin was carried out by anti-inflammatory signaling pathway of inhibiting protein expression of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappa B), and mRNA expression of TNF-alpha and IL-6, accompanied by the anti-apoptotic signaling pathway of deactivation of extracellular-regulated kinase (ERK), Jun kinase (JNK) and p38, and inhibition of activity of caspase-3. Therefore, these studies highlighted the confirmation of isoquercetin, a flavonoid compound, as an anti-inflammation and anti-apoptosis factor which might be used as a therapeutic strategy for the ischemia/reperfusion (I/R) brain injury and related diseases. (C) 2013 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000328872300004
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/137910
Collection中国科学院大连化学物理研究所
Affiliation1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
Recommended Citation
GB/T 7714
Wang, Cai-Ping,Li, Jian-Long,Zhang, Lu-Zhong,et al. Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway[J]. NEUROCHEMISTRY INTERNATIONAL,2013,63(8):741-749.
APA Wang, Cai-Ping.,Li, Jian-Long.,Zhang, Lu-Zhong.,Zhang, Xiao-Chuan.,Yu, Shu.,...&Wang, Zhi-Wei.(2013).Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway.NEUROCHEMISTRY INTERNATIONAL,63(8),741-749.
MLA Wang, Cai-Ping,et al."Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway".NEUROCHEMISTRY INTERNATIONAL 63.8(2013):741-749.
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