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Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway
Wang, Cai-Ping1; Li, Jian-Long1; Zhang, Lu-Zhong1; Zhang, Xiao-Chuan1; Yu, Shu1; Liang, Xin-Miao1,2; Ding, Fei1; Wang, Zhi-Wei1,3
关键词Isoquercetin Oxygen-glucose Deprivation Followed By Reperfusion (Ogd/r) Ischemia Apoptosis Inflammation
刊名NEUROCHEMISTRY INTERNATIONAL
2013-12-01
DOI10.1016/j.neuint.2013.09.018
63期:8页:741-749
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]FOCAL CEREBRAL-ISCHEMIA ; TOLL-LIKE RECEPTOR-4 ; NF-KAPPA-B ; EXPERIMENTAL STROKE ; BRAIN-INJURY ; IN-VITRO ; TERMINAL KINASE ; MICE ; CELLS ; INFLAMMATION
英文摘要In the present study, oxygen-glucose deprivation followed by reperfusion (OGD/R), an in vitro model of ischemia, was used to evaluate the neuroprotective effect of isoquercetin in primary culture of rat cortical neuronal cells. It was found that isoquercetin administered prior to the insult could prevent OGD/R-induced intracellular calcium concentrations ([Ca2+](i)) increase, lactate dehydrogenase (LDH) release and cell viability decrease. For the first time, isoquercetin is described as a neuroprotective agent that potentially explains the alleviation and prevention from OGD/R-induced injury in neurons. Mechanistic studies showed that the neuroprotective effect of isoquercetin was carried out by anti-inflammatory signaling pathway of inhibiting protein expression of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappa B), and mRNA expression of TNF-alpha and IL-6, accompanied by the anti-apoptotic signaling pathway of deactivation of extracellular-regulated kinase (ERK), Jun kinase (JNK) and p38, and inhibition of activity of caspase-3. Therefore, these studies highlighted the confirmation of isoquercetin, a flavonoid compound, as an anti-inflammation and anti-apoptosis factor which might be used as a therapeutic strategy for the ischemia/reperfusion (I/R) brain injury and related diseases. (C) 2013 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000328872300004
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/137910
专题中国科学院大连化学物理研究所
作者单位1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
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Wang, Cai-Ping,Li, Jian-Long,Zhang, Lu-Zhong,et al. Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway[J]. NEUROCHEMISTRY INTERNATIONAL,2013,63(8):741-749.
APA Wang, Cai-Ping.,Li, Jian-Long.,Zhang, Lu-Zhong.,Zhang, Xiao-Chuan.,Yu, Shu.,...&Wang, Zhi-Wei.(2013).Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway.NEUROCHEMISTRY INTERNATIONAL,63(8),741-749.
MLA Wang, Cai-Ping,et al."Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kappa B signal pathway".NEUROCHEMISTRY INTERNATIONAL 63.8(2013):741-749.
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