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题名: Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier
作者: Liu, Xiangyou1, 6;  Wei, Wei2;  Huang, Shijiao3, 4;  Lin, Shrong-Shi1;  Zhang, Xin5;  Zhang, Chuanmao3, 4;  Du, Yuguang6;  Ma, Guanghui2;  Li, Mei7;  Mann, Stephen7;  Ma, Ding1
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2013
DOI: 10.1039/c3tb20081g
卷: 1, 期:25, 页:3136-3143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
英文摘要: Chemotherapy has been widely used in clinical practice for cancer treatment. A major challenge for a successful chemotherapy is to potentiate the anticancer activity, whilst reducing the severe side effects. In this context, we design a bio-inspired protein-gold nanoconstruct (denoted as AFt-Au hereafter) with a core-void-shell structure which exhibits a high selectivity towards carcinoma cells. Anticancer drug 5-fluorouracil (5-FU) can be sequestered into the void space of the construct to produce an integrated nanoscale hybrid AFt-AuFU that exhibits an increased cellular uptake of 5-FU. More importantly, AFt-Au, serving as a bio-nano-chemosensitizer, renders carcinoma cells more susceptible to 5-FU by cell-cycle regulation, and thus, leads to a dramatic decrease of the IC50 value (i.e. the drug concentration required to kill 50% of the cell population) of 5-FU in HepG2 cells from 138.3 mu M to 9.2 mu M. Besides HepG2 cells, a remarkably enhanced anticancer efficacy and potentially reduced side effects are also achieved in other cell lines. Our further work reveals that the drug 5-FU is internalized into cells with AFt-Au primarily via receptor-mediated endocytosis (RME). After internalization, AFt-AuFU colocalizes with lysosomes which trigger the release of 5-FU under acidic conditions. Overall, our approach provides a novel procedure in nanoscience that promises an optimal chemotherapeutic outcome.
关键词[WOS]: HORSE SPLEEN APOFERRITIN ;  CANCER-CELLS ;  FERRITIN RECEPTORS ;  ANTICANCER DRUGS ;  PHASE-TRANSITION ;  CELLULAR UPTAKE ;  IRON RELEASE ;  CYCLIN-E ;  NANOPARTICLES ;  5-FLUOROURACIL
语种: 英语
WOS记录号: WOS:000319965800002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/137948
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Peking Univ, MOE Key Lab Cell Proliferat & Differentiat, Coll Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Coll Life Sci, Beijing 100871, Peoples R China
5.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
6.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
7.Univ Bristol, Sch Chem, Ctr Organized Matter Chem, Bristol BS6 1TS, Avon, England

Recommended Citation:
Liu, Xiangyou,Wei, Wei,Huang, Shijiao,et al. Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(25):3136-3143.
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