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A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease
Wang, Xia1; Xu, Xue1; Tao, Weiyang1; Li, Yan2; Wang, Yonghua1,3; Yang, Ling4
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2012
DOI10.1155/2012/519031
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]IN-VITRO ; SALVIA-MILTIORRHIZA ; MYOCARDIAL-INFARCTION ; DRUG ; RECEPTOR ; GROWTH ; ISOFLAVONES ; INHIBITION ; FLAVONOIDS ; APOPTOSIS
英文摘要Background. Clinical trials reveal that multiherb prescriptions of herbal medicine often exhibit pharmacological and therapeutic superiority in comparison to isolated single constituents. However, the synergistic mechanisms underlying this remain elusive. To address this question, a novel systems biology model integrating oral bioavailability and drug-likeness screening, target identification, and network pharmacology method has been constructed and applied to four clinically widely used herbs Radix Astragali Mongolici, Radix Puerariae Lobatae, Radix Ophiopogonis Japonici, and Radix Salviae Miltiorrhiza which exert synergistic effects of combined treatment of cardiovascular disease (CVD). Results. The results show that the structural properties of molecules in four herbs have substantial differences, and each herb can interact with significant target proteins related to CVD. Moreover, the bioactive ingredients from different herbs potentially act on the same molecular target (multiple-drug-one-target) and/or the functionally diverse targets but with potentially clinically relevant associations (multiple-drug-multiple-target-one-disease). From a molecular/systematic level, this explains why the herbs within a concoction could mutually enhance pharmacological synergy on a disease. Conclusions. The present work provides a new strategy not only for the understanding of pharmacological synergy in herbal medicine, but also for the rational discovery of potent drug/herb combinations that are individually subtherapeutic.
语种英语
WOS记录号WOS:000312021100001
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138006
专题中国科学院大连化学物理研究所
作者单位1.NW A&F Univ, Coll Life Sci, Ctr Bioinformat, Yangling 712100, Shaanxi, Peoples R China
2.Dalian Univ Technol, Sch Chem Engn, Dalian 116024, Liaoning, Peoples R China
3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
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Wang, Xia,Xu, Xue,Tao, Weiyang,et al. A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012.
APA Wang, Xia,Xu, Xue,Tao, Weiyang,Li, Yan,Wang, Yonghua,&Yang, Ling.(2012).A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Wang, Xia,et al."A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012).
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