中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Enhancement of Surface Graft Density of MPEG on Alginate/Chitosan Hydrogel Microcapsules for Protein Repellency
作者: Zheng, Jiani1, 5;  Xie, Hongguo1;  Yu, Weiting1;  Tan, Mingqian1;  Gong, Faquan2;  Liu, Xiudong4;  Wang, Feng3;  Lv, Guojun1;  Liu, Wanfa2;  Zheng, Guoshuang1, 5;  Yang, Yan1, 5;  Xie, Weiyang1;  Ma, Xiaojun1
刊名: LANGMUIR
发表日期: 2012-09-18
DOI: 10.1021/la302615t
卷: 28, 期:37, 页:13261-13273
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: Alginate/chitosan/alginate (ACA) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (MPEG) to improve protein repellency and biocompatibility. Increased MPEG surface graft density (n(S)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness, and grafting method. X-ray photoelectron spectroscopy (XPS) model was employed to quantitatively analyze n(S) on this three-dimensional (3D) hydrogel network structure. Our results indicated that neutralizing with alginate, increasing membrane thickness, and in situ covalent grafting could increase n(S) effectively. ACAC(PEG) was more promising than ACC(PEG) in protein repellency because alginate supplied more -COO- negative binding sites and prevented MPEG from diffusing. The n(S) increased with membrane thickness, showing better protein repellency. Moreover, the in situ covalent grafting provided an effective way to enhance n(S), and 1.00 +/- 0.03 chains/nm(2) was achieved, exhibiting almost complete immunity to protein adsorption. This antifouling hydrogel biomaterial is expected to be useful in transplantation in vivo.
关键词[WOS]: RAY PHOTOELECTRON-SPECTROSCOPY ;  POLY(ETHYLENE GLYCOL) ;  FIBRINOGEN ADSORPTION ;  CELL ENCAPSULATION ;  POLYMER BRUSHES ;  OXIDE SURFACES ;  CHITOSAN ;  RESISTANCE ;  BIOCOMPATIBILITY ;  NANOPARTICLES
语种: 英语
WOS记录号: WOS:000308787700017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138035
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Coil Efficiency & Opt Resonator, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Opt Fabricat & Coating, Dalian 116023, Peoples R China
4.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Zheng, Jiani,Xie, Hongguo,Yu, Weiting,et al. Enhancement of Surface Graft Density of MPEG on Alginate/Chitosan Hydrogel Microcapsules for Protein Repellency[J]. LANGMUIR,2012,28(37):13261-13273.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Zheng, Jiani]'s Articles
 [Xie, Hongguo]'s Articles
 [Yu, Weiting]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Zheng, Jiani]‘s Articles
 [Xie, Hongguo]‘s Articles
 [Yu, Weiting]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace