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题名: Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro
作者: Yang, Xiaohan1, 2;  Xiong, Hai5;  Guan, Zhu-Zhu1, 2;  Okai, Isaac1, 2;  Ye, Dongmei1, 3;  Song, Yang1, 2;  Li, Xiao4;  Wang, Lan1, 2;  Liu, Lu1, 2;  Du, Sha1, 2;  Lin, Dongmei6;  Shao, Shujuan1, 2
关键词: Small cell lung cancer ;  Caveolin-1 ;  Apoptosis
刊名: CANCER INVESTIGATION
发表日期: 2012-07-01
DOI: 10.3109/07357907.2012.675384
卷: 30, 期:6, 页:453-462
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology
研究领域[WOS]: Oncology
英文摘要: Small cell lung cancer (SCLC) is the most aggressive type of lung cancer, and its treatment is closely associated with apoptosis. Caveolin-1 plays an important role in the development of a variety of human cancers. This study sought to investigate the influence of Caveolin-1 on the apoptosis of SCLC in vitro. We demonstrate that higher expression of Caveolin-1 leads to inhibition of cisplatin and Ultraviolet Radiation (UVR)-induced apoptosis in SCLC cells; and also could decrease caspase-3 activity and increase the stability of Bcl-2 at the protein level. Our findings illuminate a potential molecular mechanism regarding CAV-1's role as anti-apoptosis protein.
关键词[WOS]: OUTER MITOCHONDRIAL-MEMBRANE ;  PROSTATE-CANCER ;  MOLECULAR-BASIS ;  BCL-2 ;  CARCINOMA ;  RECEPTOR ;  PHASE ;  STAGE ;  CHEMOTHERAPY ;  METASTASIS
语种: 英语
WOS记录号: WOS:000304751300002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138039
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Dept Histol & Embryol, Dalian 116044, Peoples R China
2.Dalian Med Univ, Liaoning Prov Prote Key Lab, Dalian 116044, Peoples R China
3.Dalian Univ Technol, Dept Anat, Coll Med, Dalian, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Dalian 116044, Peoples R China
6.Chinese Acad Med Sci, Dept Pathol, Beijing 100730, Peoples R China

Recommended Citation:
Yang, Xiaohan,Xiong, Hai,Guan, Zhu-Zhu,et al. Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro[J]. CANCER INVESTIGATION,2012,30(6):453-462.
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