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题名: beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells
作者: Zhao, Yong-Shun1;  Zhu, Ting-Zhun1;  Chen, Yan-Wei2;  Yao, Yi-Qun1;  Wu, Chun-Ming1;  Wei, Zhen-Qing1;  Wang, Wei3;  Xu, Ying-Hui1
关键词: beta-Elemene ;  Hsp90/Raf-1 ;  MAPK ;  Apoptosis ;  Glioblastoma cell
刊名: JOURNAL OF NEURO-ONCOLOGY
发表日期: 2012-04-01
DOI: 10.1007/s11060-011-0770-7
卷: 107, 期:2, 页:307-314
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology ;  Clinical Neurology
研究领域[WOS]: Oncology ;  Neurosciences & Neurology
英文摘要: beta-Elemene, an active component of herb medicine Curcuma wenyujin, has been shown to antagonize glioblastoma cells by inducing apoptosis. However, how beta-elemene induces apoptosis of these cells remains unclear. In this study, we report that beta-elemene disrupted the formation of the Hsp90/Raf-1 complex, a key step in maintaining the conformation stability of Raf-1, and caused deactivation of Raf-1 and inhibition of the ERK pathway, thereby leading to apoptosis of glioblastoma cells. Specifically, treatment of glioblastoma cell lines with beta-elemene attenuated phosphorylation of multiple members of the kinase families in the Ras/Raf/MEK/ERK cascade, including Raf-1 and ERK as well as downstream signaling targets such as Bcl-2. These results suggest that the Hsp90/Raf-1 complex could be a promising molecular target for new drug development for the treatment of glioblastoma.
关键词[WOS]: IN-VITRO ;  MITOCHONDRIA ;  PATHWAY ;  HSP90 ;  RAF-1 ;  BCL-2 ;  ERK ;  COMBINATION ;  CARCINOMA ;  SURVIVAL
语种: 英语
WOS记录号: WOS:000303469000010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138080
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Dalian 116011, Peoples R China
2.Dalian Med Univ, Dept Clin Pharm, Affiliated Hosp 1, Dalian 116011, Peoples R China
3.Chinese Acad Sci, Lab Biomed Mat Engn, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Zhao, Yong-Shun,Zhu, Ting-Zhun,Chen, Yan-Wei,et al. beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells[J]. JOURNAL OF NEURO-ONCOLOGY,2012,107(2):307-314.
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