DICP OpenIR
beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells
Zhao, Yong-Shun1; Zhu, Ting-Zhun1; Chen, Yan-Wei2; Yao, Yi-Qun1; Wu, Chun-Ming1; Wei, Zhen-Qing1; Wang, Wei3; Xu, Ying-Hui1
KeywordBeta-elemene Hsp90/raf-1 Mapk Apoptosis Glioblastoma Cell
Source PublicationJOURNAL OF NEURO-ONCOLOGY
2012-04-01
DOI10.1007/s11060-011-0770-7
Volume107Issue:2Pages:307-314
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectOncology ; Clinical Neurology
WOS Research AreaOncology ; Neurosciences & Neurology
WOS KeywordIN-VITRO ; MITOCHONDRIA ; PATHWAY ; HSP90 ; RAF-1 ; BCL-2 ; ERK ; COMBINATION ; CARCINOMA ; SURVIVAL
Abstractbeta-Elemene, an active component of herb medicine Curcuma wenyujin, has been shown to antagonize glioblastoma cells by inducing apoptosis. However, how beta-elemene induces apoptosis of these cells remains unclear. In this study, we report that beta-elemene disrupted the formation of the Hsp90/Raf-1 complex, a key step in maintaining the conformation stability of Raf-1, and caused deactivation of Raf-1 and inhibition of the ERK pathway, thereby leading to apoptosis of glioblastoma cells. Specifically, treatment of glioblastoma cell lines with beta-elemene attenuated phosphorylation of multiple members of the kinase families in the Ras/Raf/MEK/ERK cascade, including Raf-1 and ERK as well as downstream signaling targets such as Bcl-2. These results suggest that the Hsp90/Raf-1 complex could be a promising molecular target for new drug development for the treatment of glioblastoma.
Language英语
WOS IDWOS:000303469000010
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138080
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Dalian 116011, Peoples R China
2.Dalian Med Univ, Dept Clin Pharm, Affiliated Hosp 1, Dalian 116011, Peoples R China
3.Chinese Acad Sci, Lab Biomed Mat Engn, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yong-Shun,Zhu, Ting-Zhun,Chen, Yan-Wei,et al. beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells[J]. JOURNAL OF NEURO-ONCOLOGY,2012,107(2):307-314.
APA Zhao, Yong-Shun.,Zhu, Ting-Zhun.,Chen, Yan-Wei.,Yao, Yi-Qun.,Wu, Chun-Ming.,...&Xu, Ying-Hui.(2012).beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.JOURNAL OF NEURO-ONCOLOGY,107(2),307-314.
MLA Zhao, Yong-Shun,et al."beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells".JOURNAL OF NEURO-ONCOLOGY 107.2(2012):307-314.
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