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题名: Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1
作者: Peter, Christoph1, 7;  Waibel, Michaela1;  Keppeler, Hildegard1;  Lehmann, Rainer2;  Xu, Guowang5;  Halama, Anna6;  Adamski, Jerzy6;  Schulze-Osthoff, Klaus3;  Wesselborg, Sebastian1, 7;  Lauber, Kirsten1, 4
关键词: Apoptosis ;  chemotaxis ;  'find-me' signal ;  lysophosphatidylcholine ;  ATP-binding cassette transporter
刊名: AUTOIMMUNITY
发表日期: 2012-12-01
DOI: 10.3109/08916934.2012.719947
卷: 45, 期:8, 页:568-573
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Immunology
研究领域[WOS]: Immunology
英文摘要: Efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. A major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (LPC). So far, however, the mechanisms underlying LPC release are poorly understood. In this study, we demonstrate that pharmacological inhibition and RNAi-mediated knock-down of the lipid transporter ABCA1 in apoptotic cells completely abolished phagocyte attraction. Moreover, ectopic expression of ABCA1 significantly enhanced monocyte migration to supernatants of apoptotic cells. Hence, ABCA1 represents a novel regulator of LPC release during apoptosis.
关键词[WOS]: TANGIER-DISEASE ;  CELL-DEATH ;  ENGULFMENT ;  CLEARANCE ;  PHAGOCYTOSIS ;  MIGRATION ;  ELEGANS ;  ABC1 ;  ACT
语种: 英语
WOS记录号: WOS:000310148300002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138091
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Dept Internal Med 1, Tubingen, Germany
2.Univ Tubingen, Dept Internal Med 4, Tubingen, Germany
3.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany
4.Univ Munich, Dept Radiat Oncol, Munich, Germany
5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
6.Helmholtz Ctr Munich, Genome Anal Ctr, Inst Expt Genet, Munich, Germany
7.Univ Dusseldorf, Inst Mol Med, D-40225 Dusseldorf, Germany

Recommended Citation:
Peter, Christoph,Waibel, Michaela,Keppeler, Hildegard,et al. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1[J]. AUTOIMMUNITY,2012,45(8):568-573.
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