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Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1
Peter, Christoph1,7; Waibel, Michaela1; Keppeler, Hildegard1; Lehmann, Rainer2; Xu, Guowang5; Halama, Anna6; Adamski, Jerzy6; Schulze-Osthoff, Klaus3; Wesselborg, Sebastian1,7; Lauber, Kirsten1,4
关键词Apoptosis Chemotaxis 'find-me' Signal Lysophosphatidylcholine Atp-binding Cassette Transporter
刊名AUTOIMMUNITY
2012-12-01
DOI10.3109/08916934.2012.719947
45期:8页:568-573
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]TANGIER-DISEASE ; CELL-DEATH ; ENGULFMENT ; CLEARANCE ; PHAGOCYTOSIS ; MIGRATION ; ELEGANS ; ABC1 ; ACT
英文摘要Efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. A major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (LPC). So far, however, the mechanisms underlying LPC release are poorly understood. In this study, we demonstrate that pharmacological inhibition and RNAi-mediated knock-down of the lipid transporter ABCA1 in apoptotic cells completely abolished phagocyte attraction. Moreover, ectopic expression of ABCA1 significantly enhanced monocyte migration to supernatants of apoptotic cells. Hence, ABCA1 represents a novel regulator of LPC release during apoptosis.
语种英语
WOS记录号WOS:000310148300002
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138091
专题中国科学院大连化学物理研究所
作者单位1.Univ Tubingen, Dept Internal Med 1, Tubingen, Germany
2.Univ Tubingen, Dept Internal Med 4, Tubingen, Germany
3.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany
4.Univ Munich, Dept Radiat Oncol, Munich, Germany
5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
6.Helmholtz Ctr Munich, Genome Anal Ctr, Inst Expt Genet, Munich, Germany
7.Univ Dusseldorf, Inst Mol Med, D-40225 Dusseldorf, Germany
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Peter, Christoph,Waibel, Michaela,Keppeler, Hildegard,et al. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1[J]. AUTOIMMUNITY,2012,45(8):568-573.
APA Peter, Christoph.,Waibel, Michaela.,Keppeler, Hildegard.,Lehmann, Rainer.,Xu, Guowang.,...&Lauber, Kirsten.(2012).Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.AUTOIMMUNITY,45(8),568-573.
MLA Peter, Christoph,et al."Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1".AUTOIMMUNITY 45.8(2012):568-573.
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