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Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1
Peter, Christoph1,7; Waibel, Michaela1; Keppeler, Hildegard1; Lehmann, Rainer2; Xu, Guowang5; Halama, Anna6; Adamski, Jerzy6; Schulze-Osthoff, Klaus3; Wesselborg, Sebastian1,7; Lauber, Kirsten1,4
KeywordApoptosis Chemotaxis 'find-me' Signal Lysophosphatidylcholine Atp-binding Cassette Transporter
Source PublicationAUTOIMMUNITY
2012-12-01
DOI10.3109/08916934.2012.719947
Volume45Issue:8Pages:568-573
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectImmunology
WOS Research AreaImmunology
WOS KeywordTANGIER-DISEASE ; CELL-DEATH ; ENGULFMENT ; CLEARANCE ; PHAGOCYTOSIS ; MIGRATION ; ELEGANS ; ABC1 ; ACT
AbstractEfficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. A major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (LPC). So far, however, the mechanisms underlying LPC release are poorly understood. In this study, we demonstrate that pharmacological inhibition and RNAi-mediated knock-down of the lipid transporter ABCA1 in apoptotic cells completely abolished phagocyte attraction. Moreover, ectopic expression of ABCA1 significantly enhanced monocyte migration to supernatants of apoptotic cells. Hence, ABCA1 represents a novel regulator of LPC release during apoptosis.
Language英语
WOS IDWOS:000310148300002
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138091
Collection中国科学院大连化学物理研究所
Affiliation1.Univ Tubingen, Dept Internal Med 1, Tubingen, Germany
2.Univ Tubingen, Dept Internal Med 4, Tubingen, Germany
3.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany
4.Univ Munich, Dept Radiat Oncol, Munich, Germany
5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
6.Helmholtz Ctr Munich, Genome Anal Ctr, Inst Expt Genet, Munich, Germany
7.Univ Dusseldorf, Inst Mol Med, D-40225 Dusseldorf, Germany
Recommended Citation
GB/T 7714
Peter, Christoph,Waibel, Michaela,Keppeler, Hildegard,et al. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1[J]. AUTOIMMUNITY,2012,45(8):568-573.
APA Peter, Christoph.,Waibel, Michaela.,Keppeler, Hildegard.,Lehmann, Rainer.,Xu, Guowang.,...&Lauber, Kirsten.(2012).Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.AUTOIMMUNITY,45(8),568-573.
MLA Peter, Christoph,et al."Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1".AUTOIMMUNITY 45.8(2012):568-573.
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