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Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage
Liu, Han1; Wu, Hui1,2; Kuwada, Takao4; Okada, Hiroyuki4; Cong, Wei1; Wang, Xiaoying1,5; Sun, Guangwei3; Xu, Xiaoxi3; Sakae, Toshiro4; Xiao, Jing1
KeywordRetinoic Acid Cleft Palate Wnt Signals Animal Model Perinatal Stage
Source PublicationJOURNAL OF HARD TISSUE BIOLOGY
2012-04-01
Volume21Issue:2Pages:173-179
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Biomedical
WOS Research AreaEngineering
WOS KeywordTISSUE ; REGENERATION ; RECEPTOR ; GSK-3 ; MICE
AbstractSignaling pathways have been shown to participate in the process of Retinoic acid (RA) - induced cleft palate (CP). In our current study, the signaling molecules of GSK-3 beta, Fzd3 and beta-TrCP, which all relate with Wnt pathway, were screened from the palate tissues of the RA-induced CP in mice by the Gene-chip Technology. But, their expression pattern and level in palates during perinatal stages have not been known yet. In the studies, mRNA level of GSK-3 beta, Fzd3 and beta-TrCP were detected by quantitative real-time PCR, and showed significant difference between the Embryonic day 18 (ED18) before birth and Postnatal day 0 (PD0) after birth, as well as between the RA-induced CP and wild type during the perinatal stage, respectively. And the localization pattern of GSK-3 beta, Fzd3 and beta-TrCP proteins in palates was also characterized. Our data indicates that the Wnt signaling pathway may involve in the RA-induced cleft palate during peirnatal stage.
Language英语
WOS IDWOS:000304867000012
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138097
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Med Univ, Dept Oral Biol, Coll Stomatol, Dalian 116044, Peoples R China
2.Hainan Med Collage Hosp, Dept Stomatol, Haikou, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
4.Nihon Univ, Sch Dent Matsudo, Dept Histol, Matsudo, Chiba, Japan
5.China Natl Pwtroleum Corp, Cent Hosp, Dept Stomatol, Langfang, Peoples R China
Recommended Citation
GB/T 7714
Liu, Han,Wu, Hui,Kuwada, Takao,et al. Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage[J]. JOURNAL OF HARD TISSUE BIOLOGY,2012,21(2):173-179.
APA Liu, Han.,Wu, Hui.,Kuwada, Takao.,Okada, Hiroyuki.,Cong, Wei.,...&Xiao, Jing.(2012).Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage.JOURNAL OF HARD TISSUE BIOLOGY,21(2),173-179.
MLA Liu, Han,et al."Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage".JOURNAL OF HARD TISSUE BIOLOGY 21.2(2012):173-179.
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