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题名: Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage
作者: Liu, Han1;  Wu, Hui1, 2;  Kuwada, Takao4;  Okada, Hiroyuki4;  Cong, Wei1;  Wang, Xiaoying1, 5;  Sun, Guangwei3;  Xu, Xiaoxi3;  Sakae, Toshiro4;  Xiao, Jing1
关键词: Retinoic acid ;  Cleft palate ;  Wnt Signals ;  Animal model ;  Perinatal stage
刊名: JOURNAL OF HARD TISSUE BIOLOGY
发表日期: 2012-04-01
卷: 21, 期:2, 页:173-179
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical
研究领域[WOS]: Engineering
英文摘要: Signaling pathways have been shown to participate in the process of Retinoic acid (RA) - induced cleft palate (CP). In our current study, the signaling molecules of GSK-3 beta, Fzd3 and beta-TrCP, which all relate with Wnt pathway, were screened from the palate tissues of the RA-induced CP in mice by the Gene-chip Technology. But, their expression pattern and level in palates during perinatal stages have not been known yet. In the studies, mRNA level of GSK-3 beta, Fzd3 and beta-TrCP were detected by quantitative real-time PCR, and showed significant difference between the Embryonic day 18 (ED18) before birth and Postnatal day 0 (PD0) after birth, as well as between the RA-induced CP and wild type during the perinatal stage, respectively. And the localization pattern of GSK-3 beta, Fzd3 and beta-TrCP proteins in palates was also characterized. Our data indicates that the Wnt signaling pathway may involve in the RA-induced cleft palate during peirnatal stage.
关键词[WOS]: TISSUE ;  REGENERATION ;  RECEPTOR ;  GSK-3 ;  MICE
语种: 英语
WOS记录号: WOS:000304867000012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138097
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Dept Oral Biol, Coll Stomatol, Dalian 116044, Peoples R China
2.Hainan Med Collage Hosp, Dept Stomatol, Haikou, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
4.Nihon Univ, Sch Dent Matsudo, Dept Histol, Matsudo, Chiba, Japan
5.China Natl Pwtroleum Corp, Cent Hosp, Dept Stomatol, Langfang, Peoples R China

Recommended Citation:
Liu, Han,Wu, Hui,Kuwada, Takao,et al. Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage[J]. JOURNAL OF HARD TISSUE BIOLOGY,2012,21(2):173-179.
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