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题名: GC-MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis
作者: Zhang, Wan1;  Zhang, Liangxiao1, 2;  Li, Hongdong1;  Liang, Yizeng1;  Hu, Rong3;  Liang, Nannan1;  Fan, Wei1;  Cao, Dongsheng1;  Yi, Lunzhao1;  Xia, Jidong1
关键词: Gas chromatography-mass spectrometry ;  Postoperative cognitive dysfunction ;  Metabolic profiling ;  Subwindow permutation analysis ;  Biomarker discovery
刊名: CHROMATOGRAPHIA
发表日期: 2012-07-01
DOI: 10.1007/s10337-012-2246-0
卷: 75, 期:13-14, 页:799-808
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Postoperative cognitive dysfunction (POCD) is a subtle cognitive dysfunction, especially memory impairment for weeks or months after surgery. The underlying pathophysiological mechanism of POCD is still unclear. The aim of this study was to exploratively investigate the potential mechanism of POCD by identifying the differences among metabolic profiles of control rats, POCD and no-POCD rats after isoflurane anesthesia based on GC-MS, and subsequently discovering POCD biomarkers. In this paper, a feature-variable selection method, subwindow permutation analysis (SPA), was employed to seek the key metabolites distinguishing POCD from control group, POCD from no-POCD group. Fortunately, two key metabolites, hexadecanoic acid and myo-Inositol, were both screened out for discriminating POCD and control, POCD and no-POCD rats. It suggested that they may reveal the disturbances between POCD and control, POCD and no-POCD rats, which may be the potential biomarkers of POCD. Furthermore, related possible pathogenesis was taken into account on the basis of the relevant literatures and pathway databases. It suggested that POCD was probably related to disturbed hexadecanoic acid metabolism and myo-Inositol metabolism. All the results demonstrated that the proposed metabolic profiling approach and SPA method may be effective for exploring metabolic perturbations and possible biomarkers for POCD.
关键词[WOS]: INCREASED CEREBRAL MYOINOSITOL ;  EVOLVING LATENT PROJECTIONS ;  2-WAY MULTICOMPONENT DATA ;  MODEL POPULATION ANALYSIS ;  ALZHEIMERS-DISEASE ;  PROTEIN ;  METABOLITES ;  RESOLUTION ;  NEURONS ;  PATHWAY
语种: 英语
WOS记录号: WOS:000305796400013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138101
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China
2.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Cent S Univ, Dept Anaesthesia, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

Recommended Citation:
Zhang, Wan,Zhang, Liangxiao,Li, Hongdong,et al. GC-MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis[J]. CHROMATOGRAPHIA,2012,75(13-14):799-808.
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