DICP OpenIR
GC-MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis
Zhang, Wan1; Zhang, Liangxiao1,2; Li, Hongdong1; Liang, Yizeng1; Hu, Rong3; Liang, Nannan1; Fan, Wei1; Cao, Dongsheng1; Yi, Lunzhao1; Xia, Jidong1
KeywordGas Chromatography-mass Spectrometry Postoperative Cognitive Dysfunction Metabolic Profiling Subwindow Permutation Analysis Biomarker Discovery
Source PublicationCHROMATOGRAPHIA
2012-07-01
DOI10.1007/s10337-012-2246-0
Volume75Issue:13-14Pages:799-808
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordINCREASED CEREBRAL MYOINOSITOL ; EVOLVING LATENT PROJECTIONS ; 2-WAY MULTICOMPONENT DATA ; MODEL POPULATION ANALYSIS ; ALZHEIMERS-DISEASE ; PROTEIN ; METABOLITES ; RESOLUTION ; NEURONS ; PATHWAY
AbstractPostoperative cognitive dysfunction (POCD) is a subtle cognitive dysfunction, especially memory impairment for weeks or months after surgery. The underlying pathophysiological mechanism of POCD is still unclear. The aim of this study was to exploratively investigate the potential mechanism of POCD by identifying the differences among metabolic profiles of control rats, POCD and no-POCD rats after isoflurane anesthesia based on GC-MS, and subsequently discovering POCD biomarkers. In this paper, a feature-variable selection method, subwindow permutation analysis (SPA), was employed to seek the key metabolites distinguishing POCD from control group, POCD from no-POCD group. Fortunately, two key metabolites, hexadecanoic acid and myo-Inositol, were both screened out for discriminating POCD and control, POCD and no-POCD rats. It suggested that they may reveal the disturbances between POCD and control, POCD and no-POCD rats, which may be the potential biomarkers of POCD. Furthermore, related possible pathogenesis was taken into account on the basis of the relevant literatures and pathway databases. It suggested that POCD was probably related to disturbed hexadecanoic acid metabolism and myo-Inositol metabolism. All the results demonstrated that the proposed metabolic profiling approach and SPA method may be effective for exploring metabolic perturbations and possible biomarkers for POCD.
Language英语
WOS IDWOS:000305796400013
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138101
Collection中国科学院大连化学物理研究所
Affiliation1.Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China
2.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Cent S Univ, Dept Anaesthesia, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Wan,Zhang, Liangxiao,Li, Hongdong,et al. GC-MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis[J]. CHROMATOGRAPHIA,2012,75(13-14):799-808.
APA Zhang, Wan.,Zhang, Liangxiao.,Li, Hongdong.,Liang, Yizeng.,Hu, Rong.,...&Xia, Jidong.(2012).GC-MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis.CHROMATOGRAPHIA,75(13-14),799-808.
MLA Zhang, Wan,et al."GC-MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis".CHROMATOGRAPHIA 75.13-14(2012):799-808.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Wan]'s Articles
[Zhang, Liangxiao]'s Articles
[Li, Hongdong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Wan]'s Articles
[Zhang, Liangxiao]'s Articles
[Li, Hongdong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Wan]'s Articles
[Zhang, Liangxiao]'s Articles
[Li, Hongdong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.