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题名: Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity
作者: Liu, Rong1, 2;  He, Bin1;  Li, Dong1;  Lai, Yusi1;  Tang, James Z.3;  Gu, Zhongwei1
关键词: Poly(L-histidine) ;  Triblock copolymers ;  pH-sensitivity
刊名: POLYMER
发表日期: 2012-03-22
DOI: 10.1016/j.polymer.2012.02.013
卷: 53, 期:7, 页:1473-1482
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
英文摘要: In this paper, amphiphilic biodegradable methoxy-poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with pH sensitivity were synthesized. The properties of mPEG-PH-PLLA triblock copolymers were investigated by GPC, H-1 NMR, DSC, TGA, XRD and polarized optical microscopy. The results showed that the thermal properties of the triblock copolymers varied with the chain length of PH blocks. The glass transition temperatures (Tg) of the triblock copolymers increased with increasing poly(L-histidine) chain length. The morphologies of PLLA crystals changed from spherulite to dendritic crystal. Moreover, the crystallization rate of triblock copolymers was faster than that of PLLA homopolymer. The pH sensitivity of the self-assembled mPEG PH PLLA nanoparticles was investigated. The mean diameter and morphology of the nanoparticles were characterized by DLS. AFM and TEM. The results showed that the mean diameter of mPEG(45)-PH30-PLLA(82) nanoparticles in pH = 5.0 was smaller than that in pH = 7.4. (C) 2012 Elsevier Ltd. All rights reserved.
关键词[WOS]: RING-OPENING POLYMERIZATION ;  BLOCK-COPOLYMER MICELLES ;  INTRACELLULAR DRUG-DELIVERY ;  POTENTIAL CARRIER ;  AQUEOUS-SOLUTIONS ;  ANTICANCER DRUGS ;  POLYMERS ;  RELEASE ;  GLYCOL) ;  DOXORUBICIN
语种: 英语
WOS记录号: WOS:000301911800006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138103
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Wolverhampton Univ, Sch Appl Sci, Dept Pharm, Wolverhampton WV1 1SB, England

Recommended Citation:
Liu, Rong,He, Bin,Li, Dong,et al. Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity[J]. POLYMER,2012,53(7):1473-1482.
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