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Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity
Liu, Rong1,2; He, Bin1; Li, Dong1; Lai, Yusi1; Tang, James Z.3; Gu, Zhongwei1
KeywordPoly(L-histidine) Triblock Copolymers Ph-sensitivity
Source PublicationPOLYMER
2012-03-22
DOI10.1016/j.polymer.2012.02.013
Volume53Issue:7Pages:1473-1482
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectPolymer Science
WOS Research AreaPolymer Science
WOS KeywordRING-OPENING POLYMERIZATION ; BLOCK-COPOLYMER MICELLES ; INTRACELLULAR DRUG-DELIVERY ; POTENTIAL CARRIER ; AQUEOUS-SOLUTIONS ; ANTICANCER DRUGS ; POLYMERS ; RELEASE ; GLYCOL) ; DOXORUBICIN
AbstractIn this paper, amphiphilic biodegradable methoxy-poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with pH sensitivity were synthesized. The properties of mPEG-PH-PLLA triblock copolymers were investigated by GPC, H-1 NMR, DSC, TGA, XRD and polarized optical microscopy. The results showed that the thermal properties of the triblock copolymers varied with the chain length of PH blocks. The glass transition temperatures (Tg) of the triblock copolymers increased with increasing poly(L-histidine) chain length. The morphologies of PLLA crystals changed from spherulite to dendritic crystal. Moreover, the crystallization rate of triblock copolymers was faster than that of PLLA homopolymer. The pH sensitivity of the self-assembled mPEG PH PLLA nanoparticles was investigated. The mean diameter and morphology of the nanoparticles were characterized by DLS. AFM and TEM. The results showed that the mean diameter of mPEG(45)-PH30-PLLA(82) nanoparticles in pH = 5.0 was smaller than that in pH = 7.4. (C) 2012 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000301911800006
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138103
Collection中国科学院大连化学物理研究所
Affiliation1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Wolverhampton Univ, Sch Appl Sci, Dept Pharm, Wolverhampton WV1 1SB, England
Recommended Citation
GB/T 7714
Liu, Rong,He, Bin,Li, Dong,et al. Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity[J]. POLYMER,2012,53(7):1473-1482.
APA Liu, Rong,He, Bin,Li, Dong,Lai, Yusi,Tang, James Z.,&Gu, Zhongwei.(2012).Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity.POLYMER,53(7),1473-1482.
MLA Liu, Rong,et al."Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity".POLYMER 53.7(2012):1473-1482.
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