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Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity
Liu, Rong1,2; He, Bin1; Li, Dong1; Lai, Yusi1; Tang, James Z.3; Gu, Zhongwei1
关键词Poly(L-histidine) Triblock Copolymers Ph-sensitivity
刊名POLYMER
2012-03-22
DOI10.1016/j.polymer.2012.02.013
53期:7页:1473-1482
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]RING-OPENING POLYMERIZATION ; BLOCK-COPOLYMER MICELLES ; INTRACELLULAR DRUG-DELIVERY ; POTENTIAL CARRIER ; AQUEOUS-SOLUTIONS ; ANTICANCER DRUGS ; POLYMERS ; RELEASE ; GLYCOL) ; DOXORUBICIN
英文摘要In this paper, amphiphilic biodegradable methoxy-poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with pH sensitivity were synthesized. The properties of mPEG-PH-PLLA triblock copolymers were investigated by GPC, H-1 NMR, DSC, TGA, XRD and polarized optical microscopy. The results showed that the thermal properties of the triblock copolymers varied with the chain length of PH blocks. The glass transition temperatures (Tg) of the triblock copolymers increased with increasing poly(L-histidine) chain length. The morphologies of PLLA crystals changed from spherulite to dendritic crystal. Moreover, the crystallization rate of triblock copolymers was faster than that of PLLA homopolymer. The pH sensitivity of the self-assembled mPEG PH PLLA nanoparticles was investigated. The mean diameter and morphology of the nanoparticles were characterized by DLS. AFM and TEM. The results showed that the mean diameter of mPEG(45)-PH30-PLLA(82) nanoparticles in pH = 5.0 was smaller than that in pH = 7.4. (C) 2012 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000301911800006
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138103
专题中国科学院大连化学物理研究所
作者单位1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Wolverhampton Univ, Sch Appl Sci, Dept Pharm, Wolverhampton WV1 1SB, England
推荐引用方式
GB/T 7714
Liu, Rong,He, Bin,Li, Dong,et al. Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity[J]. POLYMER,2012,53(7):1473-1482.
APA Liu, Rong,He, Bin,Li, Dong,Lai, Yusi,Tang, James Z.,&Gu, Zhongwei.(2012).Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity.POLYMER,53(7),1473-1482.
MLA Liu, Rong,et al."Synthesis and characterization of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactide) with pH-sensitivity".POLYMER 53.7(2012):1473-1482.
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