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A phase-segregated model for plant cell culture: The effect of cell volume fraction
Zhang, W; Furusaki, S; Middelberg, APJ
KeywordPlant Cell Culture Phase-segregated Modeling Cell Volume Fraction (Cvf) Structured Model
Source PublicationJOURNAL OF CHEMICAL ENGINEERING OF JAPAN
1998-06-01
Volume31Issue:3Pages:469-474
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Chemical
WOS Research AreaEngineering
WOS KeywordCATHARANTHUS-ROSEUS ; SUSPENSION CULTURES ; STRUCTURED MODEL ; GROWTH-KINETICS ; SHAKE FLASK ; TEMPERATURE ; BIOREACTORS ; FERMENTERS
AbstractPlant cells are characterized by low water content, so the fraction of cell volume (volume fraction) in a vessel is large compared with other cell systems, even if the cell concentrations are the same. Therefore, concentration of plant cells should preferably be expressed by the liquid volume basis rather than by the total vessel volume basis. In this paper, a new model is proposed to analyze behavior of a plant cell culture by dividing the cell suspension into the biotic- and abiotic-phases, Using this model, we analyzed the cell-growth and the alkaloid production by Catharanthus roseus, Large errors in the simulated results were observed if the phase-segregation was not considered.
Language英语
WOS IDWOS:000074596600023
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138108
Collection中国科学院大连化学物理研究所
Affiliation1.Univ Adelaide, Dept Chem Engn, Adelaide, SA 5005, Australia
2.Univ Tokyo, Grad Sch Engn, Dept Chem & Biotech, Tokyo 113, Japan
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biochem Engn, Dalian 116012, Peoples R China
Recommended Citation
GB/T 7714
Zhang, W,Furusaki, S,Middelberg, APJ. A phase-segregated model for plant cell culture: The effect of cell volume fraction[J]. JOURNAL OF CHEMICAL ENGINEERING OF JAPAN,1998,31(3):469-474.
APA Zhang, W,Furusaki, S,&Middelberg, APJ.(1998).A phase-segregated model for plant cell culture: The effect of cell volume fraction.JOURNAL OF CHEMICAL ENGINEERING OF JAPAN,31(3),469-474.
MLA Zhang, W,et al."A phase-segregated model for plant cell culture: The effect of cell volume fraction".JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 31.3(1998):469-474.
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