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题名: Quantitative study of competitive binding of drugs to protein by microdialysis high performance liquid chromatography
作者: Wang, HL;  Zou, HF;  Zhang, YK
刊名: ANALYTICAL CHEMISTRY
发表日期: 1998-01-15
卷: 70, 期:2, 页:373-377
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A displacement equation describing competitive binding of drugs to protein in solution is derived and examined with four nonsteroidal anti-inflammatory drugs and human serum albumin as model drugs and protein, respectively. Microdialysis/high-performance liquid chromatography was adopted to determine simultaneously the unbound solute and displacing agent in drug-protein solutions. The method is able to locate the binding site and determine affinity constants even up to 10(7) L/mol accurately. A comparison of association constants determined by this method and from capacity factors on HSA-CSP is given.
关键词[WOS]: NONSTEROIDAL ANTIINFLAMMATORY DRUGS ;  HUMAN SERUM-ALBUMIN ;  PLASMA ;  PHASE
语种: 英语
WOS记录号: WOS:000071501800025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138159
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Acad Sinica, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Wang, HL,Zou, HF,Zhang, YK. Quantitative study of competitive binding of drugs to protein by microdialysis high performance liquid chromatography[J]. ANALYTICAL CHEMISTRY,1998,70(2):373-377.
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