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Quantitative study of competitive binding of drugs to protein by microdialysis high performance liquid chromatography
Wang, HL; Zou, HF; Zhang, YK
刊名ANALYTICAL CHEMISTRY
1998-01-15
70期:2页:373-377
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; HUMAN SERUM-ALBUMIN ; PLASMA ; PHASE
英文摘要A displacement equation describing competitive binding of drugs to protein in solution is derived and examined with four nonsteroidal anti-inflammatory drugs and human serum albumin as model drugs and protein, respectively. Microdialysis/high-performance liquid chromatography was adopted to determine simultaneously the unbound solute and displacing agent in drug-protein solutions. The method is able to locate the binding site and determine affinity constants even up to 10(7) L/mol accurately. A comparison of association constants determined by this method and from capacity factors on HSA-CSP is given.
语种英语
WOS记录号WOS:000071501800025
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138159
专题中国科学院大连化学物理研究所
作者单位Acad Sinica, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
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GB/T 7714
Wang, HL,Zou, HF,Zhang, YK. Quantitative study of competitive binding of drugs to protein by microdialysis high performance liquid chromatography[J]. ANALYTICAL CHEMISTRY,1998,70(2):373-377.
APA Wang, HL,Zou, HF,&Zhang, YK.(1998).Quantitative study of competitive binding of drugs to protein by microdialysis high performance liquid chromatography.ANALYTICAL CHEMISTRY,70(2),373-377.
MLA Wang, HL,et al."Quantitative study of competitive binding of drugs to protein by microdialysis high performance liquid chromatography".ANALYTICAL CHEMISTRY 70.2(1998):373-377.
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