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题名: Investigation of the metabolism of 7-(4-chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat
作者: Feng, N;  Zhang, Z;  An, D;  Huang, W;  Wang, G;  Han, X;  Bao, X
关键词: metabolism ;  7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride ;  rat ;  LC/MS ;  LC/NMR
刊名: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
发表日期: 1998
卷: 23, 期:1, 页:41-44
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.
语种: 英语
WOS记录号: WOS:000073649000007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138170
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.China Pharmaceut Univ, Nanjing 210009, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Feng, N,Zhang, Z,An, D,et al. Investigation of the metabolism of 7-(4-chlorbenzyl)7,8,13,13a-tetrahydroberberine chloride in the rat[J]. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,1998,23(1):41-44.
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