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Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent
Koppenhoefer, B; Epperlein, U; Schlunk, R; Zhu, XF; Lin, BC
关键词Enantiomer Separation Mobile Phase Separation Cyclodextrins Drugs Chiral
刊名JOURNAL OF CHROMATOGRAPHY A
1998-01-09
793期:1页:153-164
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]ELECTROKINETIC CHROMATOGRAPHY ; ZONE ELECTROPHORESIS ; RESOLUTION ; MICELLES ; MODEL
英文摘要In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths R-m. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization. (C) 1998 Elsevier Science B.V.
语种英语
WOS记录号WOS:000071668700015
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138176
专题中国科学院大连化学物理研究所
作者单位1.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
2.Inst Chem Phys, Dalian, Peoples R China
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Koppenhoefer, B,Epperlein, U,Schlunk, R,et al. Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent[J]. JOURNAL OF CHROMATOGRAPHY A,1998,793(1):153-164.
APA Koppenhoefer, B,Epperlein, U,Schlunk, R,Zhu, XF,&Lin, BC.(1998).Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent.JOURNAL OF CHROMATOGRAPHY A,793(1),153-164.
MLA Koppenhoefer, B,et al."Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent".JOURNAL OF CHROMATOGRAPHY A 793.1(1998):153-164.
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