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题名: Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent
作者: Koppenhoefer, B;  Epperlein, U;  Schlunk, R;  Zhu, XF;  Lin, BC
关键词: enantiomer separation ;  mobile phase separation ;  drugs, chiral ;  cyclodextrins
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 1998-01-09
卷: 793, 期:1, 页:153-164
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths R-m. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization. (C) 1998 Elsevier Science B.V.
关键词[WOS]: ELECTROKINETIC CHROMATOGRAPHY ;  ZONE ELECTROPHORESIS ;  RESOLUTION ;  MICELLES ;  MODEL
语种: 英语
WOS记录号: WOS:000071668700015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138176
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
2.Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Koppenhoefer, B,Epperlein, U,Schlunk, R,et al. Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent[J]. JOURNAL OF CHROMATOGRAPHY A,1998,793(1):153-164.
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