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题名: Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis
作者: Zhu, XF;  Lin, BC;  Epperlein, U;  Koppenhoefer, B
关键词: chiral separation ;  cyclodextrin ;  capillary electrophoresis ;  molecular mechanics
刊名: CHIRALITY
发表日期: 1999
卷: 11, 期:1, 页:56-62
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Analytical ;  Chemistry, Organic ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: beta-cyclodextrin (CD) and its derivatives HP-beta-CD, DM-beta-CD, and TM-beta-CD have been employed as chiral selectors for the separation of three nonsteroidal antiinflammatory drugs (NSAIDs) and anticoagulant at relatively low concentration (8-15 mM) by capillary zone electrophoresis (CZE). In this study, baseline separation was achieved for ibuprofen, ketoprofen, naproxen, and warfarin. It was found that the addition of 0.1% hydroxypropyl methyl cellulose (HPMC) was effective for separation. Under these conditions, the S-(+) enantiomer eluted before R-(-) in terms of ibuprofen; the calculated energy values obtained from the molecular modeling correlated well with the elution order. An equation for calculating the pK(a) values by capillary electrophoresis was introduced, and the pK(a) values of the four chiral drugs at 25 degrees C were obtained based on the equation. The value pK(a) + 0.5 is proposed to be the suitable pH of the background electrolyte for the separation of chiral compounds containing a carboxylic group. Chirality 11:56-62, 1999. (C) 1999 Wiley-Liss, Inc.
关键词[WOS]: CHIRAL STATIONARY-PHASE ;  ZONE ELECTROPHORESIS ;  ENANTIOSELECTIVE BINDING ;  SOLVATING AGENT ;  SEPARATION ;  ENANTIOSEPARATIONS ;  DISCRIMINATION ;  TEICOPLANIN ;  VANCOMYCIN ;  CONSTANTS
语种: 英语
WOS记录号: WOS:000077608600010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138207
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

Recommended Citation:
Zhu, XF,Lin, BC,Epperlein, U,et al. Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis[J]. CHIRALITY,1999,11(1):56-62.
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