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Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis
Zhu, XF; Lin, BC; Epperlein, U; Koppenhoefer, B
KeywordChiral Separation Cyclodextrin Capillary Electrophoresis Molecular Mechanics
Source PublicationCHIRALITY
1999
Volume11Issue:1Pages:56-62
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectChemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS KeywordCHIRAL STATIONARY-PHASE ; ZONE ELECTROPHORESIS ; ENANTIOSELECTIVE BINDING ; SOLVATING AGENT ; SEPARATION ; ENANTIOSEPARATIONS ; DISCRIMINATION ; TEICOPLANIN ; VANCOMYCIN ; CONSTANTS
Abstractbeta-cyclodextrin (CD) and its derivatives HP-beta-CD, DM-beta-CD, and TM-beta-CD have been employed as chiral selectors for the separation of three nonsteroidal antiinflammatory drugs (NSAIDs) and anticoagulant at relatively low concentration (8-15 mM) by capillary zone electrophoresis (CZE). In this study, baseline separation was achieved for ibuprofen, ketoprofen, naproxen, and warfarin. It was found that the addition of 0.1% hydroxypropyl methyl cellulose (HPMC) was effective for separation. Under these conditions, the S-(+) enantiomer eluted before R-(-) in terms of ibuprofen; the calculated energy values obtained from the molecular modeling correlated well with the elution order. An equation for calculating the pK(a) values by capillary electrophoresis was introduced, and the pK(a) values of the four chiral drugs at 25 degrees C were obtained based on the equation. The value pK(a) + 0.5 is proposed to be the suitable pH of the background electrolyte for the separation of chiral compounds containing a carboxylic group. Chirality 11:56-62, 1999. (C) 1999 Wiley-Liss, Inc.
Language英语
WOS IDWOS:000077608600010
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138207
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
Recommended Citation
GB/T 7714
Zhu, XF,Lin, BC,Epperlein, U,et al. Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis[J]. CHIRALITY,1999,11(1):56-62.
APA Zhu, XF,Lin, BC,Epperlein, U,&Koppenhoefer, B.(1999).Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis.CHIRALITY,11(1),56-62.
MLA Zhu, XF,et al."Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis".CHIRALITY 11.1(1999):56-62.
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