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Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis
Zhu, XF; Lin, BC; Epperlein, U; Koppenhoefer, B
关键词Chiral Separation Cyclodextrin Capillary Electrophoresis Molecular Mechanics
刊名CHIRALITY
1999
11期:1页:56-62
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]CHIRAL STATIONARY-PHASE ; ZONE ELECTROPHORESIS ; ENANTIOSELECTIVE BINDING ; SOLVATING AGENT ; SEPARATION ; ENANTIOSEPARATIONS ; DISCRIMINATION ; TEICOPLANIN ; VANCOMYCIN ; CONSTANTS
英文摘要beta-cyclodextrin (CD) and its derivatives HP-beta-CD, DM-beta-CD, and TM-beta-CD have been employed as chiral selectors for the separation of three nonsteroidal antiinflammatory drugs (NSAIDs) and anticoagulant at relatively low concentration (8-15 mM) by capillary zone electrophoresis (CZE). In this study, baseline separation was achieved for ibuprofen, ketoprofen, naproxen, and warfarin. It was found that the addition of 0.1% hydroxypropyl methyl cellulose (HPMC) was effective for separation. Under these conditions, the S-(+) enantiomer eluted before R-(-) in terms of ibuprofen; the calculated energy values obtained from the molecular modeling correlated well with the elution order. An equation for calculating the pK(a) values by capillary electrophoresis was introduced, and the pK(a) values of the four chiral drugs at 25 degrees C were obtained based on the equation. The value pK(a) + 0.5 is proposed to be the suitable pH of the background electrolyte for the separation of chiral compounds containing a carboxylic group. Chirality 11:56-62, 1999. (C) 1999 Wiley-Liss, Inc.
语种英语
WOS记录号WOS:000077608600010
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138207
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
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GB/T 7714
Zhu, XF,Lin, BC,Epperlein, U,et al. Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis[J]. CHIRALITY,1999,11(1):56-62.
APA Zhu, XF,Lin, BC,Epperlein, U,&Koppenhoefer, B.(1999).Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis.CHIRALITY,11(1),56-62.
MLA Zhu, XF,et al."Enantiomeric resolution of some nonsteroidal antiinflammatory and anticoagulant drugs using beta-cyclodextrins by capillary electrophoresis".CHIRALITY 11.1(1999):56-62.
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