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题名: Simultaneous detection of several single nucleotide polymorphisms
作者: Zhao, CX;  Shi, XZ;  Zhang, Y;  Ma, JM;  Mou, HM;  Lu, S;  Xu, GW
关键词: single nucleotide polymorphism ;  single nucleotide polymorphism analysis
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2003-08-01
卷: 31, 期:8, 页:906-910
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Accurate and fast genotyping of single nucleotide polymorphisms (SNPs) is of significant scientific importance in human genome project. Here a new automated fluorescent method that can rapidly and accurately genotype multiplex known SNPs was developed, which was achieved by substantially improving a commercially available protocol. By this method, mismatch repair gene hMLH1 and cancer repression gene P53 were investigated, eight known SNP spots (including five hot spots) of 20 coloeretal cancer patients' hMLH1 and P53 gene were detected, and a heterozygosity mutation (GTT-->GAT) at codon 384 of hMLH1 was found. Sequencing result of hMLH1 proves the reliability of this new method.
关键词[WOS]: CAPILLARY-ELECTROPHORESIS ;  HUMAN-GENOME ;  MUTATION ;  CANCER ;  HMLH1
语种: 英语
WOS记录号: WOS:000185102000003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138267
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
2.Dalian Med Univ, Attached Teaching Hosp 2, Cell Lab, Dalian 116023, Peoples R China

Recommended Citation:
Zhao, CX,Shi, XZ,Zhang, Y,et al. Simultaneous detection of several single nucleotide polymorphisms[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2003,31(8):906-910.
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