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Simultaneous detection of several single nucleotide polymorphisms
Zhao, CX; Shi, XZ; Zhang, Y; Ma, JM; Mou, HM; Lu, S; Xu, GW
关键词Single Nucleotide Polymorphism Single Nucleotide Polymorphism Analysis
刊名CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
2003-08-01
31期:8页:906-910
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]CAPILLARY-ELECTROPHORESIS ; HUMAN-GENOME ; MUTATION ; CANCER ; HMLH1
英文摘要Accurate and fast genotyping of single nucleotide polymorphisms (SNPs) is of significant scientific importance in human genome project. Here a new automated fluorescent method that can rapidly and accurately genotype multiplex known SNPs was developed, which was achieved by substantially improving a commercially available protocol. By this method, mismatch repair gene hMLH1 and cancer repression gene P53 were investigated, eight known SNP spots (including five hot spots) of 20 coloeretal cancer patients' hMLH1 and P53 gene were detected, and a heterozygosity mutation (GTT-->GAT) at codon 384 of hMLH1 was found. Sequencing result of hMLH1 proves the reliability of this new method.
语种英语
WOS记录号WOS:000185102000003
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138267
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
2.Dalian Med Univ, Attached Teaching Hosp 2, Cell Lab, Dalian 116023, Peoples R China
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GB/T 7714
Zhao, CX,Shi, XZ,Zhang, Y,et al. Simultaneous detection of several single nucleotide polymorphisms[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2003,31(8):906-910.
APA Zhao, CX.,Shi, XZ.,Zhang, Y.,Ma, JM.,Mou, HM.,...&Xu, GW.(2003).Simultaneous detection of several single nucleotide polymorphisms.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,31(8),906-910.
MLA Zhao, CX,et al."Simultaneous detection of several single nucleotide polymorphisms".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 31.8(2003):906-910.
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