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题名: Interaction of metalloenzyme with small molecules studied by microdialysis/HPLC
作者: Guo, M;  Kong, L;  Li, X;  Zou, HF
关键词: microdialysis ;  complex ;  superoxide dismutase ;  interaction
刊名: ACTA CHIMICA SINICA
发表日期: 2003
卷: 61, 期:1, 页:95-99
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: In this paper, a method of microdialysis coupled with high performance liquid chromatography (HPLC was established to study the quantitative interaction of superoxide dismutase ( Cu2Zn2SOD) with histidine and histidine-metal ion complexes. It was observed that not only histidine, but also histidine-Co(II) and histidine-Ni (II) could induce and substitute some Cu(II) and Zn(II) from Cu2Zn2SOD, eventually influence the activity of this metalloenzyme. Histidine-metal ion complexes have stronger ability than histidine to displace the bound metal ion from SOD. In addition, the amount of foreign metal ion binding to the SOD was less than that of metal ion lost from SOD. It obviously means that there was apoenzyme in the solution.
关键词[WOS]: ZINC SUPEROXIDE-DISMUTASE ;  LIQUID-CHROMATOGRAPHY ;  BINDING ;  COPPER ;  PROTEIN
语种: 英语
WOS记录号: WOS:000180546100018
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138271
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Acad Sinica, Natl Chromatog R & A Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
2.Dalian Univ Technol, Dept Chem & Chem Technol, Dalian 116622, Peoples R China

Recommended Citation:
Guo, M,Kong, L,Li, X,et al. Interaction of metalloenzyme with small molecules studied by microdialysis/HPLC[J]. ACTA CHIMICA SINICA,2003,61(1):95-99.
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