DICP OpenIR
Highly enantioselective 1,4-conjugate addition of diethylzinc to acyclic enones with chiral phosphite-pyridine ligands derived from H-8-NOBIN
Hu, YC; Liang, XM; Wang, JW; Zheng, Z; Hu, XQ
Source PublicationTETRAHEDRON-ASYMMETRY
2003-12-12
DOI10.1016/j.tetasy.2003.09.020
Volume14Issue:24Pages:3907-3915
Indexed BySCI ; IC ; CCR
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
WOS Research AreaChemistry
WOS KeywordASYMMETRIC CONJUGATE ADDITION ; COPPER-CATALYZED 1,4-ADDITION ; ALPHA-DEHYDROAMINO ACIDS ; LINEAR ALIPHATIC ENONES ; DIELS-ALDER REACTION ; NI-AL ALLOY ; CYCLIC ENONES ; PHOSPHORUS LIGANDS ; ORGANOZINC REAGENTS ; ORGANOMETALLIC REAGENTS
AbstractA series of new phosphite-pyridine ligands, based on the H-8-binaphthyl backbone, were synthesized and employed in the copper-catalyzed enantioselective 1,4-conjugate addition of diethylzinc to acyclic enones. Ligands derived from (S)-H-8-NOBIN provided better results than their parent ligands in the reaction. Ligand L1 provided excellent ees for trans -4-aryl-3-buten-2-ones (up to 97.8% ee) as substrates. Ligand L2 was very efficient for various para-chalcones, and up to 97.2% ee was achieved. (C) 2003 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000187222000015
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138272
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Hu, YC,Liang, XM,Wang, JW,et al. Highly enantioselective 1,4-conjugate addition of diethylzinc to acyclic enones with chiral phosphite-pyridine ligands derived from H-8-NOBIN[J]. TETRAHEDRON-ASYMMETRY,2003,14(24):3907-3915.
APA Hu, YC,Liang, XM,Wang, JW,Zheng, Z,&Hu, XQ.(2003).Highly enantioselective 1,4-conjugate addition of diethylzinc to acyclic enones with chiral phosphite-pyridine ligands derived from H-8-NOBIN.TETRAHEDRON-ASYMMETRY,14(24),3907-3915.
MLA Hu, YC,et al."Highly enantioselective 1,4-conjugate addition of diethylzinc to acyclic enones with chiral phosphite-pyridine ligands derived from H-8-NOBIN".TETRAHEDRON-ASYMMETRY 14.24(2003):3907-3915.
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