DICP OpenIR
An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy
Zhang, ZL; Zou, WG; Luo, CX; Li, BH; Wang, JH; Sun, LY; Qian, QJ; Liu, XY
关键词Zd55-gene Oncolytic Adenovirus E1b 55-kd Gene Cancer Gene-virotherapy
刊名CELL RESEARCH
2003-12-01
13期:6页:481-489
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]SELECTIVELY-REPLICATING ADENOVIRUS ; COMPETENT ADENOVIRUS ; THERAPEUTIC VIRUSES ; GENE DELIVERY ; TUMOR-CELLS ; NECK-CANCER ; E3 REGION ; ONYX-015 ; CARCINOMA ; E1B-55K
英文摘要ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of E1B55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each individual component in vivo.
语种英语
WOS记录号WOS:000187857000007
引用统计
被引频次:101[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138316
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Biotechnol Lab, Shanghai 200031, Peoples R China
2.Second Mil Med Univ, Eastern Hepatobiliary Hosp, Shanghai 200438, Peoples R China
推荐引用方式
GB/T 7714
Zhang, ZL,Zou, WG,Luo, CX,et al. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy[J]. CELL RESEARCH,2003,13(6):481-489.
APA Zhang, ZL.,Zou, WG.,Luo, CX.,Li, BH.,Wang, JH.,...&Liu, XY.(2003).An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy.CELL RESEARCH,13(6),481-489.
MLA Zhang, ZL,et al."An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy".CELL RESEARCH 13.6(2003):481-489.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, ZL]的文章
[Zou, WG]的文章
[Luo, CX]的文章
百度学术
百度学术中相似的文章
[Zhang, ZL]的文章
[Zou, WG]的文章
[Luo, CX]的文章
必应学术
必应学术中相似的文章
[Zhang, ZL]的文章
[Zou, WG]的文章
[Luo, CX]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。