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题名: An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy
作者: Zhang, ZL;  Zou, WG;  Luo, CX;  Li, BH;  Wang, JH;  Sun, LY;  Qian, QJ;  Liu, XY
关键词: ZD55-gene ;  oncolytic adenovirus ;  E1B 55-kD gene ;  cancer Gene-ViroTherapy
刊名: CELL RESEARCH
发表日期: 2003-12-01
卷: 13, 期:6, 页:481-489
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
英文摘要: ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of E1B55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each individual component in vivo.
关键词[WOS]: SELECTIVELY-REPLICATING ADENOVIRUS ;  COMPETENT ADENOVIRUS ;  THERAPEUTIC VIRUSES ;  GENE DELIVERY ;  TUMOR-CELLS ;  NECK-CANCER ;  E3 REGION ;  ONYX-015 ;  CARCINOMA ;  E1B-55K
语种: 英语
WOS记录号: WOS:000187857000007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138316
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Biotechnol Lab, Shanghai 200031, Peoples R China
2.Second Mil Med Univ, Eastern Hepatobiliary Hosp, Shanghai 200438, Peoples R China

Recommended Citation:
Zhang, ZL,Zou, WG,Luo, CX,et al. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy[J]. CELL RESEARCH,2003,13(6):481-489.
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