DICP OpenIR
Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients
Mei, SR; Cai, LS; Yao, QH; Xing, J; Xu, GW; Wu, CY
关键词8-hydroxydroxydeoxyguanosine Capillary Electrophoresis With End-column Amprometric Detection Method Dynamic Ph Junction Injection Cancer
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2003-11-01
24期:11页:1987-1989
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]OXIDATIVE DNA-DAMAGE ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTROCHEMICAL DETECTION ; BASE
英文摘要Using one step solid-phase extraction for urine pretreatment and a new sample focusing mode-dynamic pH junction injection for increasing sensitivity, a simple and sensitive method for the analysis of urinary 8OHdG by capillary electrophoresis with end-column amprometric detection has been developed. The limit of detection was 20 nmol/L (signal to noise ratio S/N=3). The urinary concentration of 8OHdG in nine healthy persons and 28 cancer patients was determined. It was found that urinary concentration of 8OHdG in cancer patients was significantly higher than that in healthy persons[(35. 26+/-27. 96) nmol/L) vs. (13. 51+/-5. 08) nmol/L, P<0. 05], the result demonstrated that 8OHdG may be a good biomarker for measurement of oxidative DNA damage in cancer patients. Furthermore, the excretion levels of urinary 8OHdG from cancer patients receiving surgical therapy are investigated, and the results demonstrated that the smoking has a strong effect on 8OHdG content.
语种英语
WOS记录号WOS:000186799000016
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138321
专题中国科学院大连化学物理研究所
作者单位1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
2.Acad Sinica, Dalian Inst Chem Phys, Analyt Ctr State Chromatog Res, Dalian 116011, Peoples R China
推荐引用方式
GB/T 7714
Mei, SR,Cai, LS,Yao, QH,et al. Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(11):1987-1989.
APA Mei, SR,Cai, LS,Yao, QH,Xing, J,Xu, GW,&Wu, CY.(2003).Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,24(11),1987-1989.
MLA Mei, SR,et al."Capillary electrophoresis with end-column amperometric detection of urinary 8-hydroxydeoxyguanosine of cancer patients".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 24.11(2003):1987-1989.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Mei, SR]的文章
[Cai, LS]的文章
[Yao, QH]的文章
百度学术
百度学术中相似的文章
[Mei, SR]的文章
[Cai, LS]的文章
[Yao, QH]的文章
必应学术
必应学术中相似的文章
[Mei, SR]的文章
[Cai, LS]的文章
[Yao, QH]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。