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题名: Study on the interaction of metal ions in active center of nuclease P1 with CoCl2
作者: Zheng, XF;  Chi, NY;  Zhang, QF;  Yuan, YL;  Li, XY;  Hu, JH
关键词: nuclease P1 ;  CoCl2 ;  NMR ;  interaction
刊名: CHINESE JOURNAL OF INORGANIC CHEMISTRY
发表日期: 2003-04-01
卷: 19, 期:4, 页:377-380
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Inorganic & Nuclear
研究领域[WOS]: Chemistry
英文摘要: The paper using various ways, such as ICP, VIS, NMR and measurement of enzyme activity, extensively study the direct interaction of Nuclease P1 with inorganic metal. compound (CoCl2) . It has been found that in aqueous solution, there exists a direct interaction between the metal ions of the active center in the metalloenzyme (Nuclease PI) and external added CoCl2. As a result, part of the metal ions in metalloenzyme were substituted and the corresponding metalloenzyme derivatives were produced and the catalytic activity of enzyme were changed, and the H-1 NMR spectrum of Co (11)-substituted nuclease PI derivative of Co (11) in Zn2 site of active center was firstly obtained.
关键词[WOS]: PENICILLIUM-CITRINUM ;  CRYSTAL-STRUCTURE ;  SPECIFICITY ;  RESOLUTION
语种: 英语
WOS记录号: WOS:000182036800008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138352
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Coll Bioengn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Zheng, XF,Chi, NY,Zhang, QF,et al. Study on the interaction of metal ions in active center of nuclease P1 with CoCl2[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2003,19(4):377-380.
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