DICP OpenIR
Structural identification of human blood phospholipids using liquid chromatography/quadrupole-linear ion trap mass spectrometry
Wang, C; Xie, SG; Yang, J; Yang, Q; Xu, GW
KeywordPhospholipids Linear Ion Trap Ionspray Liquid Chromatography/mass Spectrometry
Source PublicationANALYTICA CHIMICA ACTA
2004-11-01
DOI10.1016/j.aca.2004.07.065
Volume525Issue:1Pages:1-10
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordCOLLISION-INDUCED DISSOCIATION ; LIGHT-SCATTERING DETECTION ; ELECTROSPRAY-IONIZATION ; GAS-CHROMATOGRAPHY ; CLASS SEPARATION ; COOKED BEEF ; GLYCEROPHOSPHOLIPIDS ; PHOSPHATIDYLCHOLINE ; LECITHINS ; DETECTOR
AbstractA normal-phase liquid chromatography/quadrupole-linear ion trap mass spectrometry method was developed for the separation and mass spectral characterization of the main phospholipid species in human blood. The instrument combines the capabilities of a triple quadrupole mass spectrometer and ion trap technology on a single platform. The optimal separation was achieved by using hexane/1-propanol as mobile phase and 0.6% formic acid, 0.06% ammonia as modifiers. The HPLC/MS technique was able to provide information about the molecular mass of individual homologues by positive and negative turbo ionspray. More complete characterization of fatty acid chains and of the polar head group was obtained by using a quadrupole collisionally activated dissociation (CAD) spectrum with ion trap sensitivity. The mass spectra and molecular species of phosphatidylserine (PS), phosphatidylethanolamine (PE), phosphatidylcholine (PC), lysophosphatidylcholine (lysoPC) and sphingomyelin (SM) are presented. (C) 2004 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000224593600001
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138407
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Dalian Ctr Hosp, Dalian 116033, Peoples R China
Recommended Citation
GB/T 7714
Wang, C,Xie, SG,Yang, J,et al. Structural identification of human blood phospholipids using liquid chromatography/quadrupole-linear ion trap mass spectrometry[J]. ANALYTICA CHIMICA ACTA,2004,525(1):1-10.
APA Wang, C,Xie, SG,Yang, J,Yang, Q,&Xu, GW.(2004).Structural identification of human blood phospholipids using liquid chromatography/quadrupole-linear ion trap mass spectrometry.ANALYTICA CHIMICA ACTA,525(1),1-10.
MLA Wang, C,et al."Structural identification of human blood phospholipids using liquid chromatography/quadrupole-linear ion trap mass spectrometry".ANALYTICA CHIMICA ACTA 525.1(2004):1-10.
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