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题名: To stretch the boundary of secondary metabolite production in plant cell-based bioprocessing: Anthocyanin as a case study
作者: Zhang, W;  Franco, C;  Curtin, C;  Conn, S
刊名: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
发表日期: 2004-12-01
期: 5, 页:264-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology ;  Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ;  Research & Experimental Medicine
英文摘要: Plant cells and tissue cultures hold great promise for controlled production of a myriad of useful secondary metabolites on demand. The current yield and productivity cannot fulfill the commercial goal of a plant cell-based bioprocess for the production of most secondary metabolites. In order to stretch the boundary, recent advances, new directions and opportunities in plant cell-based bioprocessing have been critically examined for the 10 years from 1992 to 2002. A review of the literature indicated that most of the RPD work was devoted predominantly to studies at an empirical level. A rational approach to molecular plant cell bioprocessing based on the fundamental understanding of metabolic pathways and their regulations is urgently required to stimulate further advances; however, the strategies and technical framework are still being developed. It is the aim of this review to take a step forward in framing workable strategies and technologies for molecular plant cell-based bioprocessing. Using anthocyanin biosynthesis as a case study, an integrated postgenomic approach has been proposed. This combines the functional analysis of metabolic pathways for biosynthesis of a particular metabolite from profiling of gene expression and protein expression to metabolic profiling. A global correlation not only can thus be established at the three molecular levels, but also places emphasis on the interactions between primary metabolism and secondary metabolism; between competing and/or complimentary pathways; and between biosynthetic and post-biosynthetic events.
关键词[WOS]: VINIFERA SUSPENSION-CULTURES ;  LIGHT IRRADIATION ;  JASMONIC ACID ;  BIOSYNTHESIS
语种: 英语
WOS记录号: WOS:000227895100006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138455
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Flinders Univ S Australia, Flinders Med Ctr, Sch Med, Dept Med Biotechnol, Adelaide, SA 5042, Australia
2.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China

Recommended Citation:
Zhang, W,Franco, C,Curtin, C,et al. To stretch the boundary of secondary metabolite production in plant cell-based bioprocessing: Anthocyanin as a case study[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2004(5):264-271.
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