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Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent
Koppenhoefer, B; Epperlein, U; Jakob, A; Wuerthner, S; Zhu, XF; Lin, BC
关键词Capillary Electrophoresis Enantiomer Separation Chiral Drugs Gamma-cyclodextrin Gamma-cyclodextrin
刊名CHIRALITY
1998
10期:6页:548-554
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ELECTROKINETIC CHROMATOGRAPHY ; RESOLUTION ; ISOTACHOPHORESIS ; ISOMERS
英文摘要Following an extended chiral drug screening program by capillary zone electrophoresis (CZE), the enantioseparation of 86 racemic drugs was tested with gamma-cyclodextrin as a chiral solvating agent. Unified conditions were applied to all experiments. In total, 18 drug racemates were separated, 13 entries thereof that had not been separated at the lower CSA concentration applied in an earlier stage of the project. A comparison of the data with the results obtained for alpha- and beta-cyclodextrin points to the significance of partial penetration ("side-on binding") of aryl groups into the cyclodextrin cavity. Chirality 10:548-554, 1998. (C) 1998 Wiley-Liss, Inc.
语种英语
WOS记录号WOS:000075481300008
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138490
专题中国科学院大连化学物理研究所
作者单位1.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
2.Inst Chem Phys, Dalian, Peoples R China
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GB/T 7714
Koppenhoefer, B,Epperlein, U,Jakob, A,et al. Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent[J]. CHIRALITY,1998,10(6):548-554.
APA Koppenhoefer, B,Epperlein, U,Jakob, A,Wuerthner, S,Zhu, XF,&Lin, BC.(1998).Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent.CHIRALITY,10(6),548-554.
MLA Koppenhoefer, B,et al."Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent".CHIRALITY 10.6(1998):548-554.
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