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题名: Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent
作者: Koppenhoefer, B;  Epperlein, U;  Jakob, A;  Wuerthner, S;  Zhu, XF;  Lin, BC
关键词: capillary electrophoresis ;  enantiomer separation ;  chiral drugs ;  gamma-cyclodextrin ;  gamma-cyclodextrin
刊名: CHIRALITY
发表日期: 1998
卷: 10, 期:6, 页:548-554
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Analytical ;  Chemistry, Organic ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: Following an extended chiral drug screening program by capillary zone electrophoresis (CZE), the enantioseparation of 86 racemic drugs was tested with gamma-cyclodextrin as a chiral solvating agent. Unified conditions were applied to all experiments. In total, 18 drug racemates were separated, 13 entries thereof that had not been separated at the lower CSA concentration applied in an earlier stage of the project. A comparison of the data with the results obtained for alpha- and beta-cyclodextrin points to the significance of partial penetration ("side-on binding") of aryl groups into the cyclodextrin cavity. Chirality 10:548-554, 1998. (C) 1998 Wiley-Liss, Inc.
关键词[WOS]: ELECTROKINETIC CHROMATOGRAPHY ;  RESOLUTION ;  ISOTACHOPHORESIS ;  ISOMERS
语种: 英语
WOS记录号: WOS:000075481300008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138490
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
2.Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Koppenhoefer, B,Epperlein, U,Jakob, A,et al. Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent[J]. CHIRALITY,1998,10(6):548-554.
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